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Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges
Neurodegeneration, characterized by the progressive deterioration in neuronal structure or function, presents an elusive mechanism. The use of single-cell RNA sequencing (scRNA-seq) technology in the clinic is becoming increasingly prevalent in recent decades. This technology offers unparalleled cel...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509354/ https://www.ncbi.nlm.nih.gov/pubmed/37736042 http://dx.doi.org/10.1016/j.isci.2023.107833 |
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author | Wang, Wei Li, Tianhua Wang, Zheng Yin, Yaxin Zhang, Sitao Wang, Chaodong Hu, Xinli Lu, Shibao |
author_facet | Wang, Wei Li, Tianhua Wang, Zheng Yin, Yaxin Zhang, Sitao Wang, Chaodong Hu, Xinli Lu, Shibao |
author_sort | Wang, Wei |
collection | PubMed |
description | Neurodegeneration, characterized by the progressive deterioration in neuronal structure or function, presents an elusive mechanism. The use of single-cell RNA sequencing (scRNA-seq) technology in the clinic is becoming increasingly prevalent in recent decades. This technology offers unparalleled cell-level insights into neurodegenerative diseases, establishing itself as a potent tool for elucidating these diseases underlying mechanisms. Here, we made a deep investigation for scRNA-seq research in neurodegenerative diseases using bibliometric analysis from 2009 to 2022. We observed a robust upward trajectory in the number of publications on this subject. The United States stood out as the principal contributor to this expanding field. Specifically, the University of California System exhibited notable research prowess in this field. Alzheimer disease and Parkinson disease were the diseases most frequently investigated. Key research hotspots include the creation of a molecular brain atlas and identification of vulnerable neuronal subpopulations and potential therapeutic targets at the transcriptomic level. |
format | Online Article Text |
id | pubmed-10509354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105093542023-09-21 Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges Wang, Wei Li, Tianhua Wang, Zheng Yin, Yaxin Zhang, Sitao Wang, Chaodong Hu, Xinli Lu, Shibao iScience Article Neurodegeneration, characterized by the progressive deterioration in neuronal structure or function, presents an elusive mechanism. The use of single-cell RNA sequencing (scRNA-seq) technology in the clinic is becoming increasingly prevalent in recent decades. This technology offers unparalleled cell-level insights into neurodegenerative diseases, establishing itself as a potent tool for elucidating these diseases underlying mechanisms. Here, we made a deep investigation for scRNA-seq research in neurodegenerative diseases using bibliometric analysis from 2009 to 2022. We observed a robust upward trajectory in the number of publications on this subject. The United States stood out as the principal contributor to this expanding field. Specifically, the University of California System exhibited notable research prowess in this field. Alzheimer disease and Parkinson disease were the diseases most frequently investigated. Key research hotspots include the creation of a molecular brain atlas and identification of vulnerable neuronal subpopulations and potential therapeutic targets at the transcriptomic level. Elsevier 2023-09-05 /pmc/articles/PMC10509354/ /pubmed/37736042 http://dx.doi.org/10.1016/j.isci.2023.107833 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Wang, Wei Li, Tianhua Wang, Zheng Yin, Yaxin Zhang, Sitao Wang, Chaodong Hu, Xinli Lu, Shibao Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title | Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title_full | Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title_fullStr | Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title_full_unstemmed | Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title_short | Bibliometric analysis of research on neurodegenerative diseases and single-cell RNA sequencing: Opportunities and challenges |
title_sort | bibliometric analysis of research on neurodegenerative diseases and single-cell rna sequencing: opportunities and challenges |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509354/ https://www.ncbi.nlm.nih.gov/pubmed/37736042 http://dx.doi.org/10.1016/j.isci.2023.107833 |
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