Rapid response with good toleration of sirolimus for life‐threatening neonatal lymphatic malformations

INTRODUCTION: Lymphatic malformations (LMs) are rare vascular anomalies predominantly affecting infants, which can be debilitating or life‐threatening when complicated with intralesional bleeding or infection. Effective and safe management strategies are essential in such cases. CASE PRESENTATION: We report a case series involving four Chinese neonates with life‐threatening LMs, initially treated with oral sirolimus. All patients achieved rapid relief and sustained remission, using a lower sirolimus dosage than previously recommended. Furthermore, adverse events were rarely recorded during follow‐up. CONCLUSION: Sirolimus can be considered a promising choice for neonates with intricate and life‐threatening LMs. Initiation with a reduced sirolimus dose is advisable.