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Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

There are a large number of studies that have reported benefits of tocotrienol-rich fraction (TRF) in various populations with different health status. To date, no systematic reviews have examined randomized controlled trials (RCTs) on the effect of TRF supplementations specifically in patients with...

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Autores principales: Phang, Sonia C.W., Ahmad, Badariah, Abdul Kadir, Khalid, M Palanisamy, Uma Devi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509396/
https://www.ncbi.nlm.nih.gov/pubmed/37321474
http://dx.doi.org/10.1016/j.advnut.2023.06.006
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author Phang, Sonia C.W.
Ahmad, Badariah
Abdul Kadir, Khalid
M Palanisamy, Uma Devi
author_facet Phang, Sonia C.W.
Ahmad, Badariah
Abdul Kadir, Khalid
M Palanisamy, Uma Devi
author_sort Phang, Sonia C.W.
collection PubMed
description There are a large number of studies that have reported benefits of tocotrienol-rich fraction (TRF) in various populations with different health status. To date, no systematic reviews have examined randomized controlled trials (RCTs) on the effect of TRF supplementations specifically in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aim to examine the changes in HbA1c (glycated hemoglobin), blood pressure, and serum Hs-CRP (C-reactive protein high sensitivity) levels at post-TRF supplementation. Online databases including PubMed, Scopus, OVID Medline, and Cochrane Central Register of Controlled Trials were searched from inception until March 2023 for RCTs supplementing TRF in patients with T2DM. A total of 10 studies were included in the meta-analysis to estimate the pooled effect size. The Cochrane Risk-of-Bias (RoB) Assessment Tool was utilized to evaluate the RoB in individual studies. The meta-analysis revealed that TRF supplementation at a dosage of 250–400 mg significantly decreased HbA1c (−0.23, 95% CI: −0.44, −0.02, P < 0.05, n = 754), particularly where the intervention duration is less than 6 mo (−0.47%, 95% CI: −0.90, −0.05, P < 0.05, n = 126) and where duration of diabetes is less than 10 y (−0.37, 95% CI: −0.68, −0.07, P < 0.05, n = 83). There was no significant reduction in systolic and diastolic blood pressure and serum Hs-CRP (P > 0.05). The present meta-analysis demonstrated that supplementing with TRF in patients with T2DM decreased HbA1c but does not decrease systolic and diastolic blood pressure and serum Hs-CRP.
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spelling pubmed-105093962023-09-21 Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Phang, Sonia C.W. Ahmad, Badariah Abdul Kadir, Khalid M Palanisamy, Uma Devi Adv Nutr Review There are a large number of studies that have reported benefits of tocotrienol-rich fraction (TRF) in various populations with different health status. To date, no systematic reviews have examined randomized controlled trials (RCTs) on the effect of TRF supplementations specifically in patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis aim to examine the changes in HbA1c (glycated hemoglobin), blood pressure, and serum Hs-CRP (C-reactive protein high sensitivity) levels at post-TRF supplementation. Online databases including PubMed, Scopus, OVID Medline, and Cochrane Central Register of Controlled Trials were searched from inception until March 2023 for RCTs supplementing TRF in patients with T2DM. A total of 10 studies were included in the meta-analysis to estimate the pooled effect size. The Cochrane Risk-of-Bias (RoB) Assessment Tool was utilized to evaluate the RoB in individual studies. The meta-analysis revealed that TRF supplementation at a dosage of 250–400 mg significantly decreased HbA1c (−0.23, 95% CI: −0.44, −0.02, P < 0.05, n = 754), particularly where the intervention duration is less than 6 mo (−0.47%, 95% CI: −0.90, −0.05, P < 0.05, n = 126) and where duration of diabetes is less than 10 y (−0.37, 95% CI: −0.68, −0.07, P < 0.05, n = 83). There was no significant reduction in systolic and diastolic blood pressure and serum Hs-CRP (P > 0.05). The present meta-analysis demonstrated that supplementing with TRF in patients with T2DM decreased HbA1c but does not decrease systolic and diastolic blood pressure and serum Hs-CRP. American Society for Nutrition 2023-06-14 /pmc/articles/PMC10509396/ /pubmed/37321474 http://dx.doi.org/10.1016/j.advnut.2023.06.006 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Phang, Sonia C.W.
Ahmad, Badariah
Abdul Kadir, Khalid
M Palanisamy, Uma Devi
Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effects of tocotrienol-rich fraction supplementation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509396/
https://www.ncbi.nlm.nih.gov/pubmed/37321474
http://dx.doi.org/10.1016/j.advnut.2023.06.006
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