A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance

BACKGROUND AND AIMS: The efficacy of statin therapy is hindered by intolerance to the therapy, leading to discontinuation. Variants in SLCO1B1, which encodes the hepatic transporter OATB1B1, influence statin pharmacokinetics, resulting in altered plasma concentrations of the drug and its metabolites...

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Detalles Bibliográficos
Autores principales: Bigossi, Margherita, Maroteau, Cyrielle, Dawed, Adem Y, Taylor, Alasdair, Srinivasan, Sundararajan, Melhem, Alaa’ Lufti, Pearson, Ewan R, Pola, Roberto, Palmer, Colin N A, Siddiqui, Moneeza K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509567/
https://www.ncbi.nlm.nih.gov/pubmed/37253618
http://dx.doi.org/10.1093/ehjcvp/pvad040

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