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Global patterns and correlates in the emergence of antimicrobial resistance in humans
Antimicrobial resistance (AMR) is a critical global health threat, and drivers of the emergence of novel strains of antibiotic-resistant bacteria in humans are poorly understood at the global scale. We examined correlates of AMR emergence in humans using global data on the origins of novel strains o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509571/ https://www.ncbi.nlm.nih.gov/pubmed/37727084 http://dx.doi.org/10.1098/rspb.2023.1085 |
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author | Mendelsohn, Emma Ross, Noam Zambrana-Torrelio, Carlos Van Boeckel, T. P. Laxminarayan, Ramanan Daszak, Peter |
author_facet | Mendelsohn, Emma Ross, Noam Zambrana-Torrelio, Carlos Van Boeckel, T. P. Laxminarayan, Ramanan Daszak, Peter |
author_sort | Mendelsohn, Emma |
collection | PubMed |
description | Antimicrobial resistance (AMR) is a critical global health threat, and drivers of the emergence of novel strains of antibiotic-resistant bacteria in humans are poorly understood at the global scale. We examined correlates of AMR emergence in humans using global data on the origins of novel strains of AMR bacteria from 2006 to 2017, human and livestock antibiotic use, country economic activity and reporting bias indicators. We found that AMR emergence is positively correlated with antibiotic consumption in humans. However, the relationship between AMR emergence and antibiotic consumption in livestock is modified by gross domestic product (GDP), with only higher GDP countries showing a slight positive association, a finding that differs from previous studies on the drivers of AMR prevalence. We also found that human travel may play a role in AMR emergence, likely driving the spread of novel AMR strains into countries where they are subsequently detected for the first time. Finally, we used our model to generate a country-level map of the global distribution of predicted AMR emergence risk, and compared these findings against reported AMR emergence to identify gaps in surveillance that can be used to direct prevention and intervention policies. |
format | Online Article Text |
id | pubmed-10509571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-105095712023-09-21 Global patterns and correlates in the emergence of antimicrobial resistance in humans Mendelsohn, Emma Ross, Noam Zambrana-Torrelio, Carlos Van Boeckel, T. P. Laxminarayan, Ramanan Daszak, Peter Proc Biol Sci Ecology Antimicrobial resistance (AMR) is a critical global health threat, and drivers of the emergence of novel strains of antibiotic-resistant bacteria in humans are poorly understood at the global scale. We examined correlates of AMR emergence in humans using global data on the origins of novel strains of AMR bacteria from 2006 to 2017, human and livestock antibiotic use, country economic activity and reporting bias indicators. We found that AMR emergence is positively correlated with antibiotic consumption in humans. However, the relationship between AMR emergence and antibiotic consumption in livestock is modified by gross domestic product (GDP), with only higher GDP countries showing a slight positive association, a finding that differs from previous studies on the drivers of AMR prevalence. We also found that human travel may play a role in AMR emergence, likely driving the spread of novel AMR strains into countries where they are subsequently detected for the first time. Finally, we used our model to generate a country-level map of the global distribution of predicted AMR emergence risk, and compared these findings against reported AMR emergence to identify gaps in surveillance that can be used to direct prevention and intervention policies. The Royal Society 2023-09-20 /pmc/articles/PMC10509571/ /pubmed/37727084 http://dx.doi.org/10.1098/rspb.2023.1085 Text en © 2023 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Ecology Mendelsohn, Emma Ross, Noam Zambrana-Torrelio, Carlos Van Boeckel, T. P. Laxminarayan, Ramanan Daszak, Peter Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title | Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title_full | Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title_fullStr | Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title_full_unstemmed | Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title_short | Global patterns and correlates in the emergence of antimicrobial resistance in humans |
title_sort | global patterns and correlates in the emergence of antimicrobial resistance in humans |
topic | Ecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509571/ https://www.ncbi.nlm.nih.gov/pubmed/37727084 http://dx.doi.org/10.1098/rspb.2023.1085 |
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