Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians

Bedaquiline (BDQ) use for all age groups in drug-resistant (DR) tuberculosis (TB) regimens for children may be shorter, safer, and more effective. However, the emergence of BDQ resistance reports soon after its introduction is alarming. We report the case of a 17-year-old boy, initially diagnosed wi...

Descripción completa

Detalles Bibliográficos
Autores principales: Cesilia, Citra, Tirtosudiro, Muh Akbar, Nataprawira, Heda Melinda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509653/
https://www.ncbi.nlm.nih.gov/pubmed/37736021
http://dx.doi.org/10.1016/j.idcr.2023.e01880
_version_ 1785107782360367104
author Cesilia, Citra
Tirtosudiro, Muh Akbar
Nataprawira, Heda Melinda
author_facet Cesilia, Citra
Tirtosudiro, Muh Akbar
Nataprawira, Heda Melinda
author_sort Cesilia, Citra
collection PubMed
description Bedaquiline (BDQ) use for all age groups in drug-resistant (DR) tuberculosis (TB) regimens for children may be shorter, safer, and more effective. However, the emergence of BDQ resistance reports soon after its introduction is alarming. We report the case of a 17-year-old boy, initially diagnosed with Rifampicin-resistant (RR)-TB and developed BDQ resistance during the treatment. To the best of our knowledge, this is the first report of BDQ resistance in pediatric
format Online
Article
Text
id pubmed-10509653
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-105096532023-09-21 Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians Cesilia, Citra Tirtosudiro, Muh Akbar Nataprawira, Heda Melinda IDCases Case Report Bedaquiline (BDQ) use for all age groups in drug-resistant (DR) tuberculosis (TB) regimens for children may be shorter, safer, and more effective. However, the emergence of BDQ resistance reports soon after its introduction is alarming. We report the case of a 17-year-old boy, initially diagnosed with Rifampicin-resistant (RR)-TB and developed BDQ resistance during the treatment. To the best of our knowledge, this is the first report of BDQ resistance in pediatric Elsevier 2023-08-29 /pmc/articles/PMC10509653/ /pubmed/37736021 http://dx.doi.org/10.1016/j.idcr.2023.e01880 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Cesilia, Citra
Tirtosudiro, Muh Akbar
Nataprawira, Heda Melinda
Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title_full Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title_fullStr Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title_full_unstemmed Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title_short Bedaquiline (BDQ) resistance in an adolescent with multidrug-resistant tuberculosis (MDR-TB): An alarm for pediatricians
title_sort bedaquiline (bdq) resistance in an adolescent with multidrug-resistant tuberculosis (mdr-tb): an alarm for pediatricians
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509653/
https://www.ncbi.nlm.nih.gov/pubmed/37736021
http://dx.doi.org/10.1016/j.idcr.2023.e01880
work_keys_str_mv AT cesiliacitra bedaquilinebdqresistanceinanadolescentwithmultidrugresistanttuberculosismdrtbanalarmforpediatricians
AT tirtosudiromuhakbar bedaquilinebdqresistanceinanadolescentwithmultidrugresistanttuberculosismdrtbanalarmforpediatricians
AT nataprawirahedamelinda bedaquilinebdqresistanceinanadolescentwithmultidrugresistanttuberculosismdrtbanalarmforpediatricians

Ejemplares similares