Nasopharyngeal carcinoma patient-derived xenograft mouse models reveal potential drugs targeting cell cycle, mTOR, and autophagy pathways

BACKGROUND: Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. To test preclinical NPC drugs, we established two patient-derived xenograft (PDX) mouse models, EBV-positive PDX-B13 and EBV-negative PDX-Li41, for drug screening. METHODS: Based on next generation sequ...

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Detalles Bibliográficos
Autores principales: Li, Hsin-Pai, Huang, Chen-Yang, Lui, Kar-Wai, Chao, Yin-Kai, Yeh, Chun-Nan, Lee, Li-Yu, Huang, Yenlin, Lin, Tung-Liang, Kuo, Yung-Chia, Huang, Mei-Yuan, Fan, Hsien-Chi, Lin, An-Chi, Hsieh, Chia-Hsun, Chang, Kai-Ping, Lin, Chien-Yu, Wang, Hung-Ming, Chao, Mei, Liu, Jai-Shin, Chang, Yu-Sun, Hsu, Cheng-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509698/
https://www.ncbi.nlm.nih.gov/pubmed/37713975
http://dx.doi.org/10.1016/j.tranon.2023.101785

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