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Encapsulated papillary carcinoma of the breast: A single institution experience
Encapsulated papillary carcinoma (EPC) is a relatively rare form of breast cancer. To date, no evidence-based guidelines for the treatment of EPC have been established. Between January 2015 and December 2021, patients with histologically confirmed EPC of the breast were recorded in a database by The...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509775/ https://www.ncbi.nlm.nih.gov/pubmed/37736553 http://dx.doi.org/10.3892/ol.2023.14046 |
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author | Xu, Liang Mao, Qixin Liu, Qiuming Gao, Yufeng Luo, Lihua Guo, Chungen Qu, Wei Yan, Ningning Cao, Yali |
author_facet | Xu, Liang Mao, Qixin Liu, Qiuming Gao, Yufeng Luo, Lihua Guo, Chungen Qu, Wei Yan, Ningning Cao, Yali |
author_sort | Xu, Liang |
collection | PubMed |
description | Encapsulated papillary carcinoma (EPC) is a relatively rare form of breast cancer. To date, no evidence-based guidelines for the treatment of EPC have been established. Between January 2015 and December 2021, patients with histologically confirmed EPC of the breast were recorded in a database by The Third Hospital of Nanchang City (Nanchang, China). A total of 46 patients with EPC were retrieved from the database. Age at diagnosis ranged from 41–88 years (median age, 62 years). A total of 21 of these patients had pure EPC, 6 patients had EPC associated with ductal carcinoma in situ and 19 patients had EPC associated with invasive carcinoma. The majority of EPC cases were low nuclear grade, hormone receptor-positive and human epidermal growth factor receptor-2-negative. Additionally, myoepithelial cells were always absent in the papillae of the EPC. All patients underwent lumpectomy or mastectomy with sentinel lymph node biopsy, and almost all of the patients received adjuvant hormonal therapy. Adjuvant chemotherapy was only suggested to 4 patients who were diagnosed with axillary lymph node involvement. Subsequently, the clinicopathological features of non-invasive EPC were compared with invasive EPC. The results indicated that larger tumor sizes and axillary lymph node metastases were more common in invasive tumors. During the follow-up, only 2 patients with invasive EPC experienced recurrence or metastasis. In conclusion, a substantial proportion of invasive EPC cases display aggressive characteristics and metastatic potential, despite it being considered a subtype of carcinoma in situ with excellent prognosis, and local surgical resection is the initial method of treatment. Therefore, adjuvant endocrine therapy, radiotherapy and chemotherapy should be considered in select patients, especially in those diagnosed with invasive EPC tumors. |
format | Online Article Text |
id | pubmed-10509775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-105097752023-09-21 Encapsulated papillary carcinoma of the breast: A single institution experience Xu, Liang Mao, Qixin Liu, Qiuming Gao, Yufeng Luo, Lihua Guo, Chungen Qu, Wei Yan, Ningning Cao, Yali Oncol Lett Articles Encapsulated papillary carcinoma (EPC) is a relatively rare form of breast cancer. To date, no evidence-based guidelines for the treatment of EPC have been established. Between January 2015 and December 2021, patients with histologically confirmed EPC of the breast were recorded in a database by The Third Hospital of Nanchang City (Nanchang, China). A total of 46 patients with EPC were retrieved from the database. Age at diagnosis ranged from 41–88 years (median age, 62 years). A total of 21 of these patients had pure EPC, 6 patients had EPC associated with ductal carcinoma in situ and 19 patients had EPC associated with invasive carcinoma. The majority of EPC cases were low nuclear grade, hormone receptor-positive and human epidermal growth factor receptor-2-negative. Additionally, myoepithelial cells were always absent in the papillae of the EPC. All patients underwent lumpectomy or mastectomy with sentinel lymph node biopsy, and almost all of the patients received adjuvant hormonal therapy. Adjuvant chemotherapy was only suggested to 4 patients who were diagnosed with axillary lymph node involvement. Subsequently, the clinicopathological features of non-invasive EPC were compared with invasive EPC. The results indicated that larger tumor sizes and axillary lymph node metastases were more common in invasive tumors. During the follow-up, only 2 patients with invasive EPC experienced recurrence or metastasis. In conclusion, a substantial proportion of invasive EPC cases display aggressive characteristics and metastatic potential, despite it being considered a subtype of carcinoma in situ with excellent prognosis, and local surgical resection is the initial method of treatment. Therefore, adjuvant endocrine therapy, radiotherapy and chemotherapy should be considered in select patients, especially in those diagnosed with invasive EPC tumors. D.A. Spandidos 2023-09-07 /pmc/articles/PMC10509775/ /pubmed/37736553 http://dx.doi.org/10.3892/ol.2023.14046 Text en Copyright: © Xu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Xu, Liang Mao, Qixin Liu, Qiuming Gao, Yufeng Luo, Lihua Guo, Chungen Qu, Wei Yan, Ningning Cao, Yali Encapsulated papillary carcinoma of the breast: A single institution experience |
title | Encapsulated papillary carcinoma of the breast: A single institution experience |
title_full | Encapsulated papillary carcinoma of the breast: A single institution experience |
title_fullStr | Encapsulated papillary carcinoma of the breast: A single institution experience |
title_full_unstemmed | Encapsulated papillary carcinoma of the breast: A single institution experience |
title_short | Encapsulated papillary carcinoma of the breast: A single institution experience |
title_sort | encapsulated papillary carcinoma of the breast: a single institution experience |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509775/ https://www.ncbi.nlm.nih.gov/pubmed/37736553 http://dx.doi.org/10.3892/ol.2023.14046 |
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