Reinvestigation of Passerini and Ugi scaffolds as multistep apoptotic inducers via dual modulation of caspase 3/7 and P53-MDM2 signaling for halting breast cancer

Selective induction of breast cancer apoptosis is viewed as the mainstay of various ongoing oncology drug discovery programs. Passerini scaffolds have been recently exploited as selective apoptosis inducers via a caspase 3/7 dependent pathway. Herein, the optimized Passerini caspase activators were...

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Detalles Bibliográficos
Autores principales: Ayoup, Mohammed Salah, Wahby, Yasmin, Abdel-Hamid, Hamida, Abu-Serie, Marwa M., Ramadan, Sherif, Barakat, Assem, Teleb, Mohamed, Ismail, Magda M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509784/
https://www.ncbi.nlm.nih.gov/pubmed/37736568
http://dx.doi.org/10.1039/d3ra04029a

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