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IL-33 receptor inhibition in subjects with uncontrolled asthma: A randomized, placebo-controlled trial

BACKGROUND: Most biologics for severe asthma target only type 2 immunity. Inhibition of IL-33 signaling has the potential to target type 2 and non–type 2 pathways. OBJECTIVE: This multicenter phase IIA study evaluated the safety and efficacy of GSK3772847, a human mAb directed against the IL-33 rece...

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Detalles Bibliográficos
Autores principales:	Crim, Courtney, Stone, Sally, Millar, Valerie, Lettis, Sally, Bel, Elisabeth H., Menzies-Gow, Andrew, Chanez, Pascal, Wenzel, Sally, Lugogo, Njira, Bleecker, Eugene R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10509964/ https://www.ncbi.nlm.nih.gov/pubmed/37779541 http://dx.doi.org/10.1016/j.jacig.2022.07.002

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