Cargando…
Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017
BACKGROUND: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. OBJECTIVE: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergi...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510014/ https://www.ncbi.nlm.nih.gov/pubmed/37781648 http://dx.doi.org/10.1016/j.jacig.2023.100150 |
_version_ | 1785107875828334592 |
---|---|
author | Rönmark, Eva Bunne, Joakim Bjerg, Anders Perzanowski, Matthew Winberg, Anna Andersson, Martin Platts-Mills, Thomas Hedman, Linnea |
author_facet | Rönmark, Eva Bunne, Joakim Bjerg, Anders Perzanowski, Matthew Winberg, Anna Andersson, Martin Platts-Mills, Thomas Hedman, Linnea |
author_sort | Rönmark, Eva |
collection | PubMed |
description | BACKGROUND: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. OBJECTIVE: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergic rhinitis (AR) among children in Northern Sweden. METHODS: Three cohorts of children aged 7 to 8 years participated in a skin prick test (SPT) with 10 airborne allergens in 1996, 2006, and 2017, with 2148, 1693, and 1762 participants tested, respectively, representing 87% to 90% of schoolchildren in the catchment communities. Adjusted Poisson regression was used to identify risk factors for allergic sensitization and the association with asthma and AR. RESULTS: The prevalence of any positive SPT response increased from 21% in 1996 to 30% in 2006 and remained at 30% in 2017 (P < .001). Sensitization to cat was the most common for all the years. The risk factor pattern for a positive SPT response was similar in all examinations, with positive and significant associations with a family history of allergy (risk ratio, 1.4-1.5) and negative and significant associations with having a cat at home (risk ratio, 0.7-0.8). The prevalence of physician-diagnosed asthma increased, but the association with allergic sensitization weakened. The opposite trends were found for AR—decreasing prevalence and strengthened association with allergic sensitization. CONCLUSIONS: The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR suggest secular trends in the clinical management of allergic diseases. |
format | Online Article Text |
id | pubmed-10510014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105100142023-09-29 Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 Rönmark, Eva Bunne, Joakim Bjerg, Anders Perzanowski, Matthew Winberg, Anna Andersson, Martin Platts-Mills, Thomas Hedman, Linnea J Allergy Clin Immunol Glob Original article BACKGROUND: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking. OBJECTIVE: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergic rhinitis (AR) among children in Northern Sweden. METHODS: Three cohorts of children aged 7 to 8 years participated in a skin prick test (SPT) with 10 airborne allergens in 1996, 2006, and 2017, with 2148, 1693, and 1762 participants tested, respectively, representing 87% to 90% of schoolchildren in the catchment communities. Adjusted Poisson regression was used to identify risk factors for allergic sensitization and the association with asthma and AR. RESULTS: The prevalence of any positive SPT response increased from 21% in 1996 to 30% in 2006 and remained at 30% in 2017 (P < .001). Sensitization to cat was the most common for all the years. The risk factor pattern for a positive SPT response was similar in all examinations, with positive and significant associations with a family history of allergy (risk ratio, 1.4-1.5) and negative and significant associations with having a cat at home (risk ratio, 0.7-0.8). The prevalence of physician-diagnosed asthma increased, but the association with allergic sensitization weakened. The opposite trends were found for AR—decreasing prevalence and strengthened association with allergic sensitization. CONCLUSIONS: The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR suggest secular trends in the clinical management of allergic diseases. Elsevier 2023-07-19 /pmc/articles/PMC10510014/ /pubmed/37781648 http://dx.doi.org/10.1016/j.jacig.2023.100150 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original article Rönmark, Eva Bunne, Joakim Bjerg, Anders Perzanowski, Matthew Winberg, Anna Andersson, Martin Platts-Mills, Thomas Hedman, Linnea Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title | Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_full | Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_fullStr | Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_full_unstemmed | Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_short | Prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
title_sort | prevalence and risk factors for allergic sensitization: 3 cross-sectional studies among schoolchildren from 1996 to 2017 |
topic | Original article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510014/ https://www.ncbi.nlm.nih.gov/pubmed/37781648 http://dx.doi.org/10.1016/j.jacig.2023.100150 |
work_keys_str_mv | AT ronmarkeva prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT bunnejoakim prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT bjerganders prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT perzanowskimatthew prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT winberganna prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT anderssonmartin prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT plattsmillsthomas prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 AT hedmanlinnea prevalenceandriskfactorsforallergicsensitization3crosssectionalstudiesamongschoolchildrenfrom1996to2017 |