Cargando…
Promoting metabolic inefficiency for metabolic disease
Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510070/ https://www.ncbi.nlm.nih.gov/pubmed/37736043 http://dx.doi.org/10.1016/j.isci.2023.107843 |
_version_ | 1785107886319337472 |
---|---|
author | Kazak, Lawrence |
author_facet | Kazak, Lawrence |
author_sort | Kazak, Lawrence |
collection | PubMed |
description | Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases. |
format | Online Article Text |
id | pubmed-10510070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105100702023-09-21 Promoting metabolic inefficiency for metabolic disease Kazak, Lawrence iScience Perspective Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases. Elsevier 2023-09-06 /pmc/articles/PMC10510070/ /pubmed/37736043 http://dx.doi.org/10.1016/j.isci.2023.107843 Text en © 2023 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Kazak, Lawrence Promoting metabolic inefficiency for metabolic disease |
title | Promoting metabolic inefficiency for metabolic disease |
title_full | Promoting metabolic inefficiency for metabolic disease |
title_fullStr | Promoting metabolic inefficiency for metabolic disease |
title_full_unstemmed | Promoting metabolic inefficiency for metabolic disease |
title_short | Promoting metabolic inefficiency for metabolic disease |
title_sort | promoting metabolic inefficiency for metabolic disease |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510070/ https://www.ncbi.nlm.nih.gov/pubmed/37736043 http://dx.doi.org/10.1016/j.isci.2023.107843 |
work_keys_str_mv | AT kazaklawrence promotingmetabolicinefficiencyformetabolicdisease |