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Promoting metabolic inefficiency for metabolic disease

Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy...

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Detalles Bibliográficos
Autor principal: Kazak, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510070/
https://www.ncbi.nlm.nih.gov/pubmed/37736043
http://dx.doi.org/10.1016/j.isci.2023.107843
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author Kazak, Lawrence
author_facet Kazak, Lawrence
author_sort Kazak, Lawrence
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description Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases.
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spelling pubmed-105100702023-09-21 Promoting metabolic inefficiency for metabolic disease Kazak, Lawrence iScience Perspective Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases. Elsevier 2023-09-06 /pmc/articles/PMC10510070/ /pubmed/37736043 http://dx.doi.org/10.1016/j.isci.2023.107843 Text en © 2023 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Kazak, Lawrence
Promoting metabolic inefficiency for metabolic disease
title Promoting metabolic inefficiency for metabolic disease
title_full Promoting metabolic inefficiency for metabolic disease
title_fullStr Promoting metabolic inefficiency for metabolic disease
title_full_unstemmed Promoting metabolic inefficiency for metabolic disease
title_short Promoting metabolic inefficiency for metabolic disease
title_sort promoting metabolic inefficiency for metabolic disease
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510070/
https://www.ncbi.nlm.nih.gov/pubmed/37736043
http://dx.doi.org/10.1016/j.isci.2023.107843
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