Efficient Ligand Discovery Using Sulfur(VI) Fluoride Reactive Fragments

[Image: see text] Sulfur(VI) fluorides (SFs) have emerged as valuable electrophiles for the design of “beyond-cysteine” covalent inhibitors and offer potential for expansion of the liganded proteome. Since SFs target a broad range of nucleophilic amino acids, they deliver an approach for the covalen...

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Detalles Bibliográficos
Autores principales: Aatkar, Arron, Vuorinen, Aini, Longfield, Oliver E., Gilbert, Katharine, Peltier-Heap, Rachel, Wagner, Craig D., Zappacosta, Francesca, Rittinger, Katrin, Chung, Chun-wa, House, David, Tomkinson, Nicholas C. O., Bush, Jacob T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510102/
https://www.ncbi.nlm.nih.gov/pubmed/37084287
http://dx.doi.org/10.1021/acschembio.3c00034

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