Cellular Validation of a Chemically Improved Inhibitor Identifies Monoubiquitination on OTUB2

[Image: see text] Ubiquitin thioesterase OTUB2, a cysteine protease from the ovarian tumor (OTU) deubiquitinase superfamily, is often overexpressed during tumor progression and metastasis. Development of OTUB2 inhibitors is therefore believed to be therapeutically important, yet potent and selective...

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Detalles Bibliográficos
Autores principales: Gan, Jin, de Vries, Jelle, Akkermans, Jimmy J. L. L., Mohammed, Yassene, Tjokrodirijo, Rayman T. N., de Ru, Arnoud H., Kim, Robbert Q., Vargas, David A., Pol, Vito, Fasan, Rudi, van Veelen, Peter A., Neefjes, Jacques, van Dam, Hans, Ovaa, Huib, Sapmaz, Aysegul, Geurink, Paul P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510154/
https://www.ncbi.nlm.nih.gov/pubmed/37642399
http://dx.doi.org/10.1021/acschembio.3c00227

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