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Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study

BACKGROUND: The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) analysis. METHODS: We selected genetic instruments associated with migraine from...

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Autores principales: Fang, Tian, Zhang, Zhihao, Zhou, Huijie, Wu, Wanchun, Ji, Fuqing, Zou, Liqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510189/
https://www.ncbi.nlm.nih.gov/pubmed/37730543
http://dx.doi.org/10.1186/s12885-023-11337-9
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author Fang, Tian
Zhang, Zhihao
Zhou, Huijie
Wu, Wanchun
Ji, Fuqing
Zou, Liqun
author_facet Fang, Tian
Zhang, Zhihao
Zhou, Huijie
Wu, Wanchun
Ji, Fuqing
Zou, Liqun
author_sort Fang, Tian
collection PubMed
description BACKGROUND: The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) analysis. METHODS: We selected genetic instruments associated with migraine from a recently published genome-wide association studies (GWAS). Inverse variant weighted (IVW) analysis was adopted as the main method, and we also performed the weighted-median method and the MR‒Egger, MR pleiotropy residual sum and outlier (MR-PRESSO), and MR Robust Adjusted Profile Score (MR-RAPS) methods as supplements. RESULTS: Our MR suggested that any migraine (AM) was a risk factor for overall breast cancer (IVW: odds ratio (OR) = 1.072, 95% confidence intervals (CI) = 1.035–1.110, P = 8.78 × 10(− 5), false discovery rate (FDR) = 7.36 × 10(− 4)) and estrogen receptor-positive (ER+) breast cancer (IVW: OR = 1.066, 95% CI = 1.023–1.111, P = 0.0024; FDR = 0.0108) but not estrogen receptor-negative (ER-) breast cancer. In its subtype analysis, women with a history of migraine without aura (MO) had an increased risk of ER- breast cancer (IVW: OR = 1.089, 95% CI = 1.019–1.163, P = 0.0118, FDR = 0.0354), and MO was suggestively associated with the risk of overall breast cancer (FDR > 0.05 and IVW P < 0.05). No significant heterogeneity or horizontal pleiotropy was found in the sensitivity analysis. CONCLUSION: This study suggested that women with AM have an increased risk of overall breast cancer and ER + breast cancer. MO was suggestively associated with the risk of overall breast cancer and ER- breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-11337-9.
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spelling pubmed-105101892023-09-21 Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study Fang, Tian Zhang, Zhihao Zhou, Huijie Wu, Wanchun Ji, Fuqing Zou, Liqun BMC Cancer Research BACKGROUND: The relationship between migraine and breast cancer risk has generated conflicting findings. We attempted to assess the association between migraine and breast cancer risk using Mendelian randomization (MR) analysis. METHODS: We selected genetic instruments associated with migraine from a recently published genome-wide association studies (GWAS). Inverse variant weighted (IVW) analysis was adopted as the main method, and we also performed the weighted-median method and the MR‒Egger, MR pleiotropy residual sum and outlier (MR-PRESSO), and MR Robust Adjusted Profile Score (MR-RAPS) methods as supplements. RESULTS: Our MR suggested that any migraine (AM) was a risk factor for overall breast cancer (IVW: odds ratio (OR) = 1.072, 95% confidence intervals (CI) = 1.035–1.110, P = 8.78 × 10(− 5), false discovery rate (FDR) = 7.36 × 10(− 4)) and estrogen receptor-positive (ER+) breast cancer (IVW: OR = 1.066, 95% CI = 1.023–1.111, P = 0.0024; FDR = 0.0108) but not estrogen receptor-negative (ER-) breast cancer. In its subtype analysis, women with a history of migraine without aura (MO) had an increased risk of ER- breast cancer (IVW: OR = 1.089, 95% CI = 1.019–1.163, P = 0.0118, FDR = 0.0354), and MO was suggestively associated with the risk of overall breast cancer (FDR > 0.05 and IVW P < 0.05). No significant heterogeneity or horizontal pleiotropy was found in the sensitivity analysis. CONCLUSION: This study suggested that women with AM have an increased risk of overall breast cancer and ER + breast cancer. MO was suggestively associated with the risk of overall breast cancer and ER- breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-023-11337-9. BioMed Central 2023-09-20 /pmc/articles/PMC10510189/ /pubmed/37730543 http://dx.doi.org/10.1186/s12885-023-11337-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Fang, Tian
Zhang, Zhihao
Zhou, Huijie
Wu, Wanchun
Ji, Fuqing
Zou, Liqun
Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title_full Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title_fullStr Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title_full_unstemmed Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title_short Effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
title_sort effect of genetic liability to migraine and its subtypes on breast cancer: a mendelian randomization study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510189/
https://www.ncbi.nlm.nih.gov/pubmed/37730543
http://dx.doi.org/10.1186/s12885-023-11337-9
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