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CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate

The nuclear receptor subfamily 5 group A member 1 (NR5A1), encoding steroidogenic factor 1 (SF-1), has been identified as a critical factor in gonadal development in animal studies. A previous study of ours suggested that upregulation of NR5A1 during early gonadal differentiation in male (46,XY) hum...

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Detalles Bibliográficos
Autores principales:	Danti, Laura, Lundin, Karolina, Sepponen, Kirsi, Yohannes, Dawit A., Kere, Juha, Tuuri, Timo, Tapanainen, Juha S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510196/ https://www.ncbi.nlm.nih.gov/pubmed/37726790 http://dx.doi.org/10.1186/s13048-023-01264-5

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