Dosage compensation of Z sex chromosome genes in avian fibroblast cells

In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quant...

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Detalles Bibliográficos
Autores principales: Deviatiiarov, Ruslan, Nagai, Hiroki, Ismagulov, Galym, Stupina, Anastasia, Wada, Kazuhiro, Ide, Shinji, Toji, Noriyuki, Zhang, Heng, Sukparangsi, Woranop, Intarapat, Sittipon, Gusev, Oleg, Sheng, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510239/
https://www.ncbi.nlm.nih.gov/pubmed/37730643
http://dx.doi.org/10.1186/s13059-023-03055-z
Descripción
Sumario:In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quantitative method and analyze transcriptional activities of male and female fibroblast cells from seven bird species. Our data indicate that three fourths of chrZ genes are strictly compensated across Aves, similar to mammalian chrX. We also present a complete list of non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a conserved sex-dimorphic gene in birds. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-03055-z.

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