Dosage compensation of Z sex chromosome genes in avian fibroblast cells

In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quant...

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Autores principales: Deviatiiarov, Ruslan, Nagai, Hiroki, Ismagulov, Galym, Stupina, Anastasia, Wada, Kazuhiro, Ide, Shinji, Toji, Noriyuki, Zhang, Heng, Sukparangsi, Woranop, Intarapat, Sittipon, Gusev, Oleg, Sheng, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510239/
https://www.ncbi.nlm.nih.gov/pubmed/37730643
http://dx.doi.org/10.1186/s13059-023-03055-z
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author Deviatiiarov, Ruslan
Nagai, Hiroki
Ismagulov, Galym
Stupina, Anastasia
Wada, Kazuhiro
Ide, Shinji
Toji, Noriyuki
Zhang, Heng
Sukparangsi, Woranop
Intarapat, Sittipon
Gusev, Oleg
Sheng, Guojun
author_facet Deviatiiarov, Ruslan
Nagai, Hiroki
Ismagulov, Galym
Stupina, Anastasia
Wada, Kazuhiro
Ide, Shinji
Toji, Noriyuki
Zhang, Heng
Sukparangsi, Woranop
Intarapat, Sittipon
Gusev, Oleg
Sheng, Guojun
author_sort Deviatiiarov, Ruslan
collection PubMed
description In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quantitative method and analyze transcriptional activities of male and female fibroblast cells from seven bird species. Our data indicate that three fourths of chrZ genes are strictly compensated across Aves, similar to mammalian chrX. We also present a complete list of non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a conserved sex-dimorphic gene in birds. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-03055-z.
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spelling pubmed-105102392023-09-21 Dosage compensation of Z sex chromosome genes in avian fibroblast cells Deviatiiarov, Ruslan Nagai, Hiroki Ismagulov, Galym Stupina, Anastasia Wada, Kazuhiro Ide, Shinji Toji, Noriyuki Zhang, Heng Sukparangsi, Woranop Intarapat, Sittipon Gusev, Oleg Sheng, Guojun Genome Biol Short Report In birds, sex is genetically determined; however, the molecular mechanism is not well-understood. The avian Z sex chromosome (chrZ) lacks whole chromosome inactivation, in contrast to the mammalian chrX. To investigate chrZ dosage compensation and its role in sex specification, we use a highly quantitative method and analyze transcriptional activities of male and female fibroblast cells from seven bird species. Our data indicate that three fourths of chrZ genes are strictly compensated across Aves, similar to mammalian chrX. We also present a complete list of non-compensated chrZ genes and identify Ribosomal Protein S6 (RPS6) as a conserved sex-dimorphic gene in birds. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-023-03055-z. BioMed Central 2023-09-20 /pmc/articles/PMC10510239/ /pubmed/37730643 http://dx.doi.org/10.1186/s13059-023-03055-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Deviatiiarov, Ruslan
Nagai, Hiroki
Ismagulov, Galym
Stupina, Anastasia
Wada, Kazuhiro
Ide, Shinji
Toji, Noriyuki
Zhang, Heng
Sukparangsi, Woranop
Intarapat, Sittipon
Gusev, Oleg
Sheng, Guojun
Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title_full Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title_fullStr Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title_full_unstemmed Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title_short Dosage compensation of Z sex chromosome genes in avian fibroblast cells
title_sort dosage compensation of z sex chromosome genes in avian fibroblast cells
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510239/
https://www.ncbi.nlm.nih.gov/pubmed/37730643
http://dx.doi.org/10.1186/s13059-023-03055-z
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