Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release

[Image: see text] A major drawback of cytotoxic chemotherapy is the lack of selectivity toward noncancerous cells. The targeted delivery of cytotoxic drugs to tumor cells is a longstanding goal in cancer research. We proposed that covalent inhibitors could be adapted to deliver cytotoxic agents, con...

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Detalles Bibliográficos
Autores principales: Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510387/
https://www.ncbi.nlm.nih.gov/pubmed/37647129
http://dx.doi.org/10.1021/acs.jmedchem.3c00845

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