Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what the underlying mechanisms are remain unclear. In this study, t...

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Detalles Bibliográficos
Autores principales: Liu, Zhenqing, Chao, Jianfei, Wang, Cheng, Sun, Guihua, Roeth, Daniel, Liu, Wei, Chen, Xianwei, Li, Li, Tian, E, Feng, Lizhao, Davtyan, Hayk, Blurton-Jones, Mathew, Kalkum, Markus, Shi, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510531/
https://www.ncbi.nlm.nih.gov/pubmed/37494190
http://dx.doi.org/10.1016/j.celrep.2023.112841

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