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Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest known genetic risk factor for late-onset Alzheimer’s disease. However, whether this single-nucleotide polymorphism (SNP) is functional and what the underlying mechanisms are remain unclear. In this study, t...
Autores principales: | Liu, Zhenqing, Chao, Jianfei, Wang, Cheng, Sun, Guihua, Roeth, Daniel, Liu, Wei, Chen, Xianwei, Li, Li, Tian, E, Feng, Lizhao, Davtyan, Hayk, Blurton-Jones, Mathew, Kalkum, Markus, Shi, Yanhong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510531/ https://www.ncbi.nlm.nih.gov/pubmed/37494190 http://dx.doi.org/10.1016/j.celrep.2023.112841 |
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