Pancreatic Ductal Adenocarcinoma Cells Regulate NLRP3 Activation to Generate a Tolerogenic Microenvironment

Defining feature of pancreatic ductal adenocarcinoma (PDAC) that participates in the high mortality rate and drug resistance is the immune-tolerant microenvironment which enables tumors to progress unabated by adaptive immunity. In this study, we report that PDAC cells release CSF-1 to induce nucleo...

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Detalles Bibliográficos
Autores principales: Amo-Aparicio, Jesus, Dominguez, Adrian, Atif, Shaikh M., Dinarello, Alberto, Azam, Tania, Alula, Kibrom M., Piper, Miles, Lieu, Christopher H., Lentz, Robert W., Leal, Alexis D., Bagby, Stacey M., Messersmith, Wells A., Karam, Sana D., Dinarello, Charles A., Pitts, Todd M., Marchetti, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510589/
https://www.ncbi.nlm.nih.gov/pubmed/37772994
http://dx.doi.org/10.1158/2767-9764.CRC-23-0065

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