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Multiplexed Near-Field Optical Trapping Exploiting Anapole States
[Image: see text] Optical tweezers have had a major impact on bioscience research by enabling the study of biological particles with high accuracy. The focus so far has been on trapping individual particles, ranging from the cellular to the molecular level. However, biology is intrinsically heteroge...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510711/ https://www.ncbi.nlm.nih.gov/pubmed/37603833 http://dx.doi.org/10.1021/acsnano.3c03100 |
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author | Conteduca, Donato Brunetti, Giuseppe Barth, Isabel Quinn, Steven D. Ciminelli, Caterina Krauss, Thomas F. |
author_facet | Conteduca, Donato Brunetti, Giuseppe Barth, Isabel Quinn, Steven D. Ciminelli, Caterina Krauss, Thomas F. |
author_sort | Conteduca, Donato |
collection | PubMed |
description | [Image: see text] Optical tweezers have had a major impact on bioscience research by enabling the study of biological particles with high accuracy. The focus so far has been on trapping individual particles, ranging from the cellular to the molecular level. However, biology is intrinsically heterogeneous; therefore, access to variations within the same population and species is necessary for the rigorous understanding of a biological system. Optical tweezers have demonstrated the ability of trapping multiple targets in parallel; however, the multiplexing capability becomes a challenge when moving toward the nanoscale. Here, we experimentally demonstrate a resonant metasurface that is capable of trapping a high number of nanoparticles in parallel, thereby opening up the field to large-scale multiplexed optical trapping. The unit cell of the metasurface supports an anapole state that generates a strong field enhancement for low-power near-field trapping; importantly, the anapole state is also more angle-tolerant than comparable resonant modes, which allows its excitation with a focused light beam, necessary for generating the required power density and optical forces. We use the anapole state to demonstrate the trapping of 100’s of 100 nm polystyrene beads over a 10 min period, as well as the multiplexed trapping of lipid vesicles with a moderate intensity of <250 μW/μm(2). This demonstration will enable studies relating to the heterogeneity of biological systems, such as viruses, extracellular vesicles, and other bioparticles at the nanoscale. |
format | Online Article Text |
id | pubmed-10510711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-105107112023-09-21 Multiplexed Near-Field Optical Trapping Exploiting Anapole States Conteduca, Donato Brunetti, Giuseppe Barth, Isabel Quinn, Steven D. Ciminelli, Caterina Krauss, Thomas F. ACS Nano [Image: see text] Optical tweezers have had a major impact on bioscience research by enabling the study of biological particles with high accuracy. The focus so far has been on trapping individual particles, ranging from the cellular to the molecular level. However, biology is intrinsically heterogeneous; therefore, access to variations within the same population and species is necessary for the rigorous understanding of a biological system. Optical tweezers have demonstrated the ability of trapping multiple targets in parallel; however, the multiplexing capability becomes a challenge when moving toward the nanoscale. Here, we experimentally demonstrate a resonant metasurface that is capable of trapping a high number of nanoparticles in parallel, thereby opening up the field to large-scale multiplexed optical trapping. The unit cell of the metasurface supports an anapole state that generates a strong field enhancement for low-power near-field trapping; importantly, the anapole state is also more angle-tolerant than comparable resonant modes, which allows its excitation with a focused light beam, necessary for generating the required power density and optical forces. We use the anapole state to demonstrate the trapping of 100’s of 100 nm polystyrene beads over a 10 min period, as well as the multiplexed trapping of lipid vesicles with a moderate intensity of <250 μW/μm(2). This demonstration will enable studies relating to the heterogeneity of biological systems, such as viruses, extracellular vesicles, and other bioparticles at the nanoscale. American Chemical Society 2023-08-21 /pmc/articles/PMC10510711/ /pubmed/37603833 http://dx.doi.org/10.1021/acsnano.3c03100 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Conteduca, Donato Brunetti, Giuseppe Barth, Isabel Quinn, Steven D. Ciminelli, Caterina Krauss, Thomas F. Multiplexed Near-Field Optical Trapping Exploiting Anapole States |
title | Multiplexed Near-Field
Optical Trapping Exploiting
Anapole States |
title_full | Multiplexed Near-Field
Optical Trapping Exploiting
Anapole States |
title_fullStr | Multiplexed Near-Field
Optical Trapping Exploiting
Anapole States |
title_full_unstemmed | Multiplexed Near-Field
Optical Trapping Exploiting
Anapole States |
title_short | Multiplexed Near-Field
Optical Trapping Exploiting
Anapole States |
title_sort | multiplexed near-field
optical trapping exploiting
anapole states |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10510711/ https://www.ncbi.nlm.nih.gov/pubmed/37603833 http://dx.doi.org/10.1021/acsnano.3c03100 |
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