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Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study
BACKGROUND: COVID-19 is a rapidly emerging global health threat and economic disaster. The epidemiology and outcomes of COVID-19 patients in Ethiopia are scarce. Thus, the present study aimed to assess clinical profiles, epidemiological characteristics, and treatment outcomes of patients with COVID-...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511068/ https://www.ncbi.nlm.nih.gov/pubmed/37729157 http://dx.doi.org/10.1371/journal.pgph.0002285 |
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author | Gedefie, Alemu Birara, Tadesse Misganaw, Sisay Bambo, Getachew Mesfin Kebede, Samuel Sahile Tilahun, Mihret Mohammed, Ousman Kassa, Yeshimebet Bisetegn, Habtye Alemayehu, Ermiyas |
author_facet | Gedefie, Alemu Birara, Tadesse Misganaw, Sisay Bambo, Getachew Mesfin Kebede, Samuel Sahile Tilahun, Mihret Mohammed, Ousman Kassa, Yeshimebet Bisetegn, Habtye Alemayehu, Ermiyas |
author_sort | Gedefie, Alemu |
collection | PubMed |
description | BACKGROUND: COVID-19 is a rapidly emerging global health threat and economic disaster. The epidemiology and outcomes of COVID-19 patients in Ethiopia are scarce. Thus, the present study aimed to assess clinical profiles, epidemiological characteristics, and treatment outcomes of patients with COVID-19 and to identify determinants of the disease outcome among COVID-19 patients in North-eastern Ethiopia. METHODS: A retrospective observational cohort study was conducted in North-eastern Ethiopia, from May 2020 to Jan 2022 on a total of 364 SARS-COV-2 infected patients. Demographic and clinical data were abstracted from the medical records of patients. Bivariable and multivariable analyses were conducted to determine the factors associated with the mortality of COVID-19 patients and variables with a P-value < 0.05 were considered statistically significant. RESULT: Among 364 COVID-19 patients included in this study, two-thirds (68.1%) were males with a median age of 34 years. The majority; 42.9% & 33.0% respectively cases were detected at the health facility and community level surveillance. Furthermore, 6.6% of patients had pre-existing comorbidities of which diabetes mellitus (23.1%) and hypertension (15.3%) had the highest frequency. The symptomatic rate of COVID-19 patients was 30.5%. The most common clinical presentations were cough (26.9%), fever (26.1%), and shortness of breath (15.2%). Moreover, the mortality rate of COVID-19 patients was 4.1% which was independently predicted by a history of underlining co-morbidity (AHR:6.09; 95%CI:1.299–28.56; P = 0.022) and a history of severe or critical conditions (AHR 11.8; 95%CI:4.89–28.83; P = 0.003). CONCLUSION: Severe or critical acute COVID-19 and underlining comorbidities are associated with higher mortality. Therefore, critical follow–up and management should be given to patients with underlying diseases is required. |
format | Online Article Text |
id | pubmed-10511068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105110682023-09-21 Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study Gedefie, Alemu Birara, Tadesse Misganaw, Sisay Bambo, Getachew Mesfin Kebede, Samuel Sahile Tilahun, Mihret Mohammed, Ousman Kassa, Yeshimebet Bisetegn, Habtye Alemayehu, Ermiyas PLOS Glob Public Health Research Article BACKGROUND: COVID-19 is a rapidly emerging global health threat and economic disaster. The epidemiology and outcomes of COVID-19 patients in Ethiopia are scarce. Thus, the present study aimed to assess clinical profiles, epidemiological characteristics, and treatment outcomes of patients with COVID-19 and to identify determinants of the disease outcome among COVID-19 patients in North-eastern Ethiopia. METHODS: A retrospective observational cohort study was conducted in North-eastern Ethiopia, from May 2020 to Jan 2022 on a total of 364 SARS-COV-2 infected patients. Demographic and clinical data were abstracted from the medical records of patients. Bivariable and multivariable analyses were conducted to determine the factors associated with the mortality of COVID-19 patients and variables with a P-value < 0.05 were considered statistically significant. RESULT: Among 364 COVID-19 patients included in this study, two-thirds (68.1%) were males with a median age of 34 years. The majority; 42.9% & 33.0% respectively cases were detected at the health facility and community level surveillance. Furthermore, 6.6% of patients had pre-existing comorbidities of which diabetes mellitus (23.1%) and hypertension (15.3%) had the highest frequency. The symptomatic rate of COVID-19 patients was 30.5%. The most common clinical presentations were cough (26.9%), fever (26.1%), and shortness of breath (15.2%). Moreover, the mortality rate of COVID-19 patients was 4.1% which was independently predicted by a history of underlining co-morbidity (AHR:6.09; 95%CI:1.299–28.56; P = 0.022) and a history of severe or critical conditions (AHR 11.8; 95%CI:4.89–28.83; P = 0.003). CONCLUSION: Severe or critical acute COVID-19 and underlining comorbidities are associated with higher mortality. Therefore, critical follow–up and management should be given to patients with underlying diseases is required. Public Library of Science 2023-09-20 /pmc/articles/PMC10511068/ /pubmed/37729157 http://dx.doi.org/10.1371/journal.pgph.0002285 Text en © 2023 Gedefie et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gedefie, Alemu Birara, Tadesse Misganaw, Sisay Bambo, Getachew Mesfin Kebede, Samuel Sahile Tilahun, Mihret Mohammed, Ousman Kassa, Yeshimebet Bisetegn, Habtye Alemayehu, Ermiyas Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title | Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title_full | Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title_fullStr | Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title_full_unstemmed | Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title_short | Clinical profiles, epidemiological characteristics and treatment outcomes of COVID-19 patients in North-eastern Ethiopia: A retrospective cohort study |
title_sort | clinical profiles, epidemiological characteristics and treatment outcomes of covid-19 patients in north-eastern ethiopia: a retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511068/ https://www.ncbi.nlm.nih.gov/pubmed/37729157 http://dx.doi.org/10.1371/journal.pgph.0002285 |
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