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Peri-operative pharmacokinetics of cefazolin prophylaxis during valve replacement surgery

OBJECTIVE: There is little prospective data to guide effective dosing for antibiotic prophylaxis during surgery requiring cardiopulmonary bypass (CPB). We aim to describe the effects of CPB on the population pharmacokinetics (PK) of total and unbound concentrations of cefazolin and to recommend opti...

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Detalles Bibliográficos
Autores principales:	Alli, Ahmad, Paruk, Fathima, Roger, Claire, Lipman, Jeffrey, Calleemalay, Daren, Wallis, Steven C., Scribante, Juan, Richards, Guy A., Roberts, Jason A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511078/ https://www.ncbi.nlm.nih.gov/pubmed/37729151 http://dx.doi.org/10.1371/journal.pone.0291425

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