Integrated analysis of phase 1a and 1b randomized controlled trials; Treg-targeted cancer immunotherapy with the humanized anti-CCR4 antibody, KW-0761, for advanced solid tumors

INTRODUCTION: Regulatory T cells (Tregs) have attracted attention as a novel therapeutic target to augment the clinical efficacy of immunotherapy. We conducted phase Ia and Ib trials to examine the safety and efficacy of the anti-CCR4 antibody, KW-0761 (mogamulizumab), which may eliminate effector T...

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Detalles Bibliográficos
Autores principales: Fujikawa, Kaoru, Saito, Takuro, Kurose, Koji, Kojima, Takashi, Funakoshi, Takeru, Sato, Eiichi, Kakimi, Kazuhiro, Iida, Shinsuke, Doki, Yuichiro, Oka, Mikio, Ueda, Ryuzo, Wada, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511099/
https://www.ncbi.nlm.nih.gov/pubmed/37729184
http://dx.doi.org/10.1371/journal.pone.0291772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511099/
https://www.ncbi.nlm.nih.gov/pubmed/37729184
http://dx.doi.org/10.1371/journal.pone.0291772

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