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Enhancement of in vivo targeting properties of ErbB2 aptamer by chemical modification
Aptamers have great potential for diagnostics and therapeutics due to high specificity to target molecules. However, studies have shown that aptamers are rapidly distributed and excreted from blood circulation due to nuclease degradation. To overcome this issue and to improve in vivo pharmacokinetic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511116/ https://www.ncbi.nlm.nih.gov/pubmed/37729138 http://dx.doi.org/10.1371/journal.pone.0291624 |