Breakpoints in complex chromosomal rearrangements correspond to transposase-accessible regions of DNA from mature sperm

Constitutional complex chromosomal rearrangements (CCRs) are rare cytogenetic aberrations arising in the germline via an unknown mechanism. Here we analyzed the breakpoint junctions of microscopically three-way or more complex translocations using comprehensive genomic and epigenomic analyses. All o...

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Detalles Bibliográficos
Autores principales: Sugimoto, Takeshi, Inagaki, Hidehito, Mariya, Tasuku, Kawamura, Rie, Taniguchi-Ikeda, Mariko, Mizuno, Seiji, Muramatsu, Yukako, Tsuge, Ikuya, Ohashi, Hirofumi, Saito, Nakamichi, Hasegawa, Yuiko, Ochi, Nobuhiko, Yamaguchi, Masatoshi, Murotsuki, Jun, Kurahashi, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511381/
https://www.ncbi.nlm.nih.gov/pubmed/37615740
http://dx.doi.org/10.1007/s00439-023-02591-9

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