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An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution

Planar diffractive lenses (PDLs) with optimized but disordered structures can focus light beyond the diffraction limit. However, these disordered structures have inevitably destroyed wide-field imaging capability, limiting their applications in microscopy. Here, we introduce information entropy S to...

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Autores principales: He, Jun, Zhao, Dong, Liu, Hong, Teng, Jinghua, Qiu, Cheng-Wei, Huang, Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511456/
https://www.ncbi.nlm.nih.gov/pubmed/37730672
http://dx.doi.org/10.1038/s41467-023-41605-y
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author He, Jun
Zhao, Dong
Liu, Hong
Teng, Jinghua
Qiu, Cheng-Wei
Huang, Kun
author_facet He, Jun
Zhao, Dong
Liu, Hong
Teng, Jinghua
Qiu, Cheng-Wei
Huang, Kun
author_sort He, Jun
collection PubMed
description Planar diffractive lenses (PDLs) with optimized but disordered structures can focus light beyond the diffraction limit. However, these disordered structures have inevitably destroyed wide-field imaging capability, limiting their applications in microscopy. Here, we introduce information entropy S to evaluate the disorder of an objective chip by using the probability of its structural deviation from standard Fresnel zone plates. Inspired by the theory of entropy change, we predict an equilibrium point [Formula: see text] to balance wide-field imaging (theoretically evaluated by the Strehl ratio) and subdiffraction-limit focusing. To verify this, a [Formula: see text] objective chip with a record-long focal length of 1 mm is designed with [Formula: see text] , which is the nearest to the equilibrium point among all reported PDLs. Consequently, our fabricated chip can focus light with subdiffraction-limit size of 0.44 λ and image fine details with spatial frequencies up to 4000 lp/mm experimentally. These unprecedented performances enable ultracompact reflective confocal microscopy for superresolution imaging.
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spelling pubmed-105114562023-09-22 An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution He, Jun Zhao, Dong Liu, Hong Teng, Jinghua Qiu, Cheng-Wei Huang, Kun Nat Commun Article Planar diffractive lenses (PDLs) with optimized but disordered structures can focus light beyond the diffraction limit. However, these disordered structures have inevitably destroyed wide-field imaging capability, limiting their applications in microscopy. Here, we introduce information entropy S to evaluate the disorder of an objective chip by using the probability of its structural deviation from standard Fresnel zone plates. Inspired by the theory of entropy change, we predict an equilibrium point [Formula: see text] to balance wide-field imaging (theoretically evaluated by the Strehl ratio) and subdiffraction-limit focusing. To verify this, a [Formula: see text] objective chip with a record-long focal length of 1 mm is designed with [Formula: see text] , which is the nearest to the equilibrium point among all reported PDLs. Consequently, our fabricated chip can focus light with subdiffraction-limit size of 0.44 λ and image fine details with spatial frequencies up to 4000 lp/mm experimentally. These unprecedented performances enable ultracompact reflective confocal microscopy for superresolution imaging. Nature Publishing Group UK 2023-09-20 /pmc/articles/PMC10511456/ /pubmed/37730672 http://dx.doi.org/10.1038/s41467-023-41605-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Jun
Zhao, Dong
Liu, Hong
Teng, Jinghua
Qiu, Cheng-Wei
Huang, Kun
An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title_full An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title_fullStr An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title_full_unstemmed An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title_short An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
title_sort entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511456/
https://www.ncbi.nlm.nih.gov/pubmed/37730672
http://dx.doi.org/10.1038/s41467-023-41605-y
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