Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers

An HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (nasal antibody spray or NAS) was developed to strengthen COVID-19 management. NAS exhibited potent broadly neutralizing activities against SARS-CoV-2 with PVNT(50) values ranging from 0.0035 to 3.1997 μg/ml for t...

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Autores principales: Imsuwansri, Thanarath, Jongthitinon, Thitinan, Pojdoung, Niramon, Meesiripan, Nuntana, Sakarin, Siriwan, Boonkrai, Chatikorn, Wongtangprasert, Tossapon, Phakham, Tanapati, Audomsun, Thittaya, Attakitbancha, Chadaporn, Saelao, Pijitra, Muanwien, Phijitra, Tian, Maoxin Tim, Tongchusak, Songsak, Sangruji, Bhrus, Wannigama, Dhammika Leshan, Sawangmake, Chenphop, Rodprasert, Watchareewan, Le, Quynh Dang, Purbantoro, Steven Dwi, Vasuntrarak, Kananuch, Nantavisai, Sirirat, Sirilak, Supakit, Uppapong, Ballang, Sapsutthipas, Sompong, Trisiriwanich, Sakalin, Somporn, Thitiporn, Usoo, Asmah, Mingngamsup, Natthakarn, Phumiamorn, Supaporn, Aumklad, Porawan, Arunprasert, Kwanputtha, Patrojanasophon, Prasopchai, Opanasopit, Praneet, Pesirikan, Norapath, Nitisaporn, Ladda, Pitchayakorn, Jesada, Narkthong, Thana, Mahong, Bancha, Chaiyo, Kumchol, Srisutthisamphan, Kanjana, Viriyakitkosol, Ratchanont, Aeumjaturapat, Songklot, Jongkaewwattana, Anan, Bunnag, Sakarn, Pisitkun, Trairak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511465/
https://www.ncbi.nlm.nih.gov/pubmed/37730833
http://dx.doi.org/10.1038/s41598-023-42539-7

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