Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

OBJECTIVE: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine whether Drp1 directly regulates skeletal muscle i...

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Detalles Bibliográficos
Autores principales: Kugler, Benjamin A., Lourie, Jared, Berger, Nicolas, Lin, Nana, Nguyen, Paul, DosSantos, Edzana, Ali, Abir, Sesay, Amira, Rosen, H. Grace, Kalemba, Baby, Hendricks, Gregory M., Houmard, Joseph A., Sesaki, Hiromi, Gona, Philimon, You, Tongjian, Yan, Zhen, Zou, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511484/
https://www.ncbi.nlm.nih.gov/pubmed/37690520
http://dx.doi.org/10.1016/j.molmet.2023.101802

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