Critical requirement of SOS1 for tumor development and microenvironment modulation in KRAS(G12D)-driven lung adenocarcinoma

The impact of genetic ablation of SOS1 or SOS2 is evaluated in a murine model of KRAS(G12D)-driven lung adenocarcinoma (LUAD). SOS2 ablation shows some protection during early stages but only SOS1 ablation causes significant, specific long term increase of survival/lifespan of the KRAS(G12D) mice as...

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Detalles Bibliográficos
Autores principales: Baltanás, Fernando C., García-Navas, Rósula, Rodríguez-Ramos, Pablo, Calzada, Nuria, Cuesta, Cristina, Borrajo, Javier, Fuentes-Mateos, Rocío, Olarte-San Juan, Andrea, Vidaña, Nerea, Castellano, Esther, Santos, Eugenio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511506/
https://www.ncbi.nlm.nih.gov/pubmed/37730692
http://dx.doi.org/10.1038/s41467-023-41583-1

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