Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient

To investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa, Acinetobacter baumannii; Ab and Proteus mirabilis; Pm) suspected of harbouring a carbapenemase were inves...

Descripción completa

Detalles Bibliográficos
Autores principales: Mataseje, L. F., Pitout, J., Croxen, M., Mulvey, M. R., Dingle, T. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511597/
https://www.ncbi.nlm.nih.gov/pubmed/37688673
http://dx.doi.org/10.1007/s10096-023-04651-4
_version_ 1785108177945100288
author Mataseje, L. F.
Pitout, J.
Croxen, M.
Mulvey, M. R.
Dingle, T. C.
author_facet Mataseje, L. F.
Pitout, J.
Croxen, M.
Mulvey, M. R.
Dingle, T. C.
author_sort Mataseje, L. F.
collection PubMed
description To investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa, Acinetobacter baumannii; Ab and Proteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected; bla(VIM-1) (Pa; ST773), bla(OXA-23) (Ab, ST499) and bla(NDM-1) identified in all isolates. NDM regions were found chromosomally integrated in all isolates. Data showed no evidence of NDM-1 transfer within this patient suggesting the enzyme was acquired in three separate events. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-023-04651-4.
format Online
Article
Text
id pubmed-10511597
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-105115972023-09-22 Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient Mataseje, L. F. Pitout, J. Croxen, M. Mulvey, M. R. Dingle, T. C. Eur J Clin Microbiol Infect Dis Brief Report To investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa, Acinetobacter baumannii; Ab and Proteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected; bla(VIM-1) (Pa; ST773), bla(OXA-23) (Ab, ST499) and bla(NDM-1) identified in all isolates. NDM regions were found chromosomally integrated in all isolates. Data showed no evidence of NDM-1 transfer within this patient suggesting the enzyme was acquired in three separate events. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-023-04651-4. Springer Berlin Heidelberg 2023-09-09 2023 /pmc/articles/PMC10511597/ /pubmed/37688673 http://dx.doi.org/10.1007/s10096-023-04651-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Mataseje, L. F.
Pitout, J.
Croxen, M.
Mulvey, M. R.
Dingle, T. C.
Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title_full Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title_fullStr Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title_full_unstemmed Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title_short Three separate acquisitions of bla(NDM-1) in three different bacterial species from a single patient
title_sort three separate acquisitions of bla(ndm-1) in three different bacterial species from a single patient
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511597/
https://www.ncbi.nlm.nih.gov/pubmed/37688673
http://dx.doi.org/10.1007/s10096-023-04651-4
work_keys_str_mv AT matasejelf threeseparateacquisitionsofblandm1inthreedifferentbacterialspeciesfromasinglepatient
AT pitoutj threeseparateacquisitionsofblandm1inthreedifferentbacterialspeciesfromasinglepatient
AT croxenm threeseparateacquisitionsofblandm1inthreedifferentbacterialspeciesfromasinglepatient
AT mulveymr threeseparateacquisitionsofblandm1inthreedifferentbacterialspeciesfromasinglepatient
AT dingletc threeseparateacquisitionsofblandm1inthreedifferentbacterialspeciesfromasinglepatient

Ejemplares similares