Cargando…

Self-reproduction and doubling time limits of different cellular subsystems

Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduc...

Descripción completa

Detalles Bibliográficos
Autores principales: Abner, Kristo, Šverns, Peter, Arold, Janar, Morell, Indrek, Lints, Taivo, Medri, Sander, Seiman, Andrus, Adamberg, Kaarel, Vilu, Raivo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511633/
https://www.ncbi.nlm.nih.gov/pubmed/37730753
http://dx.doi.org/10.1038/s41540-023-00306-4
_version_ 1785108186572783616
author Abner, Kristo
Šverns, Peter
Arold, Janar
Morell, Indrek
Lints, Taivo
Medri, Sander
Seiman, Andrus
Adamberg, Kaarel
Vilu, Raivo
author_facet Abner, Kristo
Šverns, Peter
Arold, Janar
Morell, Indrek
Lints, Taivo
Medri, Sander
Seiman, Andrus
Adamberg, Kaarel
Vilu, Raivo
author_sort Abner, Kristo
collection PubMed
description Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduction processes of cells as of coordinated functioning of ribosomes and the enzymatic networks of different functional complexity that support those ribosomes. We show that doubling times of proto-cells (ranging from simplest replicators up to those reaching the size of E. coli) increase rather with the number of different cell component species than with the total numbers of cell components. However, certain differences were observed between cell components in increasing the doubling times depending on the types of relationships between those cell components and ribosomes. Theoretical limits of doubling times of the self-reproducing proto-cells determined by the molecular parameters of cell components and cell processes were in the range between 6–40 min.
format Online
Article
Text
id pubmed-10511633
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-105116332023-09-22 Self-reproduction and doubling time limits of different cellular subsystems Abner, Kristo Šverns, Peter Arold, Janar Morell, Indrek Lints, Taivo Medri, Sander Seiman, Andrus Adamberg, Kaarel Vilu, Raivo NPJ Syst Biol Appl Article Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduction processes of cells as of coordinated functioning of ribosomes and the enzymatic networks of different functional complexity that support those ribosomes. We show that doubling times of proto-cells (ranging from simplest replicators up to those reaching the size of E. coli) increase rather with the number of different cell component species than with the total numbers of cell components. However, certain differences were observed between cell components in increasing the doubling times depending on the types of relationships between those cell components and ribosomes. Theoretical limits of doubling times of the self-reproducing proto-cells determined by the molecular parameters of cell components and cell processes were in the range between 6–40 min. Nature Publishing Group UK 2023-09-20 /pmc/articles/PMC10511633/ /pubmed/37730753 http://dx.doi.org/10.1038/s41540-023-00306-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Abner, Kristo
Šverns, Peter
Arold, Janar
Morell, Indrek
Lints, Taivo
Medri, Sander
Seiman, Andrus
Adamberg, Kaarel
Vilu, Raivo
Self-reproduction and doubling time limits of different cellular subsystems
title Self-reproduction and doubling time limits of different cellular subsystems
title_full Self-reproduction and doubling time limits of different cellular subsystems
title_fullStr Self-reproduction and doubling time limits of different cellular subsystems
title_full_unstemmed Self-reproduction and doubling time limits of different cellular subsystems
title_short Self-reproduction and doubling time limits of different cellular subsystems
title_sort self-reproduction and doubling time limits of different cellular subsystems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511633/
https://www.ncbi.nlm.nih.gov/pubmed/37730753
http://dx.doi.org/10.1038/s41540-023-00306-4
work_keys_str_mv AT abnerkristo selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT svernspeter selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT aroldjanar selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT morellindrek selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT lintstaivo selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT medrisander selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT seimanandrus selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT adambergkaarel selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems
AT viluraivo selfreproductionanddoublingtimelimitsofdifferentcellularsubsystems