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Self-reproduction and doubling time limits of different cellular subsystems
Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduc...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511633/ https://www.ncbi.nlm.nih.gov/pubmed/37730753 http://dx.doi.org/10.1038/s41540-023-00306-4 |
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author | Abner, Kristo Šverns, Peter Arold, Janar Morell, Indrek Lints, Taivo Medri, Sander Seiman, Andrus Adamberg, Kaarel Vilu, Raivo |
author_facet | Abner, Kristo Šverns, Peter Arold, Janar Morell, Indrek Lints, Taivo Medri, Sander Seiman, Andrus Adamberg, Kaarel Vilu, Raivo |
author_sort | Abner, Kristo |
collection | PubMed |
description | Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduction processes of cells as of coordinated functioning of ribosomes and the enzymatic networks of different functional complexity that support those ribosomes. We show that doubling times of proto-cells (ranging from simplest replicators up to those reaching the size of E. coli) increase rather with the number of different cell component species than with the total numbers of cell components. However, certain differences were observed between cell components in increasing the doubling times depending on the types of relationships between those cell components and ribosomes. Theoretical limits of doubling times of the self-reproducing proto-cells determined by the molecular parameters of cell components and cell processes were in the range between 6–40 min. |
format | Online Article Text |
id | pubmed-10511633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105116332023-09-22 Self-reproduction and doubling time limits of different cellular subsystems Abner, Kristo Šverns, Peter Arold, Janar Morell, Indrek Lints, Taivo Medri, Sander Seiman, Andrus Adamberg, Kaarel Vilu, Raivo NPJ Syst Biol Appl Article Ribosomes which can self-replicate themselves practically autonomously in beneficial physicochemical conditions have been recognized as the central organelles of cellular self-reproduction processes. The challenge of cell design is to understand and describe the rates and mechanisms of self-reproduction processes of cells as of coordinated functioning of ribosomes and the enzymatic networks of different functional complexity that support those ribosomes. We show that doubling times of proto-cells (ranging from simplest replicators up to those reaching the size of E. coli) increase rather with the number of different cell component species than with the total numbers of cell components. However, certain differences were observed between cell components in increasing the doubling times depending on the types of relationships between those cell components and ribosomes. Theoretical limits of doubling times of the self-reproducing proto-cells determined by the molecular parameters of cell components and cell processes were in the range between 6–40 min. Nature Publishing Group UK 2023-09-20 /pmc/articles/PMC10511633/ /pubmed/37730753 http://dx.doi.org/10.1038/s41540-023-00306-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Abner, Kristo Šverns, Peter Arold, Janar Morell, Indrek Lints, Taivo Medri, Sander Seiman, Andrus Adamberg, Kaarel Vilu, Raivo Self-reproduction and doubling time limits of different cellular subsystems |
title | Self-reproduction and doubling time limits of different cellular subsystems |
title_full | Self-reproduction and doubling time limits of different cellular subsystems |
title_fullStr | Self-reproduction and doubling time limits of different cellular subsystems |
title_full_unstemmed | Self-reproduction and doubling time limits of different cellular subsystems |
title_short | Self-reproduction and doubling time limits of different cellular subsystems |
title_sort | self-reproduction and doubling time limits of different cellular subsystems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511633/ https://www.ncbi.nlm.nih.gov/pubmed/37730753 http://dx.doi.org/10.1038/s41540-023-00306-4 |
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