Cdk12 maintains the integrity of adult axons by suppressing actin remodeling

The role of cyclin-dependent kinases (CDKs) that are ubiquitously expressed in the adult nervous system remains unclear. Cdk12 is enriched in terminally differentiated neurons where its conical role in the cell cycle progression is redundant. We find that in adult neurons Cdk12 acts a negative regul...

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Detalles Bibliográficos
Autores principales: Townsend, L. N., Clarke, H., Maddison, D., Jones, K. M., Amadio, L., Jefferson, A., Chughtai, U., Bis, D. M., Züchner, S., Allen, N. D., Van der Goes van Naters, W., Peters, O. M., Smith, G. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511712/
https://www.ncbi.nlm.nih.gov/pubmed/37730761
http://dx.doi.org/10.1038/s41420-023-01642-4

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