NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity

Macrophages infected with Gram-negative bacteria expressing Type III secretion system (T3SS) activate the NLRC4 inflammasome, resulting in Gasdermin D (GSDMD)-dependent, but GSDME independent IL-1β secretion and pyroptosis. Here we examine inflammasome signaling in neutrophils infected with Pseudomo...

Descripción completa

Detalles Bibliográficos
Autores principales: Minns, Martin S., Liboro, Karl, Lima, Tatiane S., Abbondante, Serena, Miller, Brandon A., Marshall, Michaela E., Tran Chau, Jolynn, Roistacher, Alicia, Rietsch, Arne, Dubyak, George R., Pearlman, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511713/
https://www.ncbi.nlm.nih.gov/pubmed/37730693
http://dx.doi.org/10.1038/s41467-023-41391-7

Ejemplares similares

Ejemplares similares