Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling

A lack of cross-disciplinary unanimity prevails within addiction research. Theories conceptualizing addiction through the three-stage brain disease model contest other theories that substance use disorder is of behavioural or genetic origin. The reverberations of this lack of consensus are noticeabl...

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Autores principales: Greener, Megan R., Storr, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511750/
https://www.ncbi.nlm.nih.gov/pubmed/37745284
http://dx.doi.org/10.3389/fnmol.2023.1166852
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author Greener, Megan R.
Storr, Sarah J.
author_facet Greener, Megan R.
Storr, Sarah J.
author_sort Greener, Megan R.
collection PubMed
description A lack of cross-disciplinary unanimity prevails within addiction research. Theories conceptualizing addiction through the three-stage brain disease model contest other theories that substance use disorder is of behavioural or genetic origin. The reverberations of this lack of consensus are noticeable throughout addiction research and within the foundations of disease modelling. The availability of methods to investigate substance use disorder are inconsistent and sometimes unrepresentative. This review discusses theories of addiction aetiology, available models for addiction research and the strengths and limitations of current practical experimental methods of study.
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spelling pubmed-105117502023-09-22 Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling Greener, Megan R. Storr, Sarah J. Front Mol Neurosci Molecular Neuroscience A lack of cross-disciplinary unanimity prevails within addiction research. Theories conceptualizing addiction through the three-stage brain disease model contest other theories that substance use disorder is of behavioural or genetic origin. The reverberations of this lack of consensus are noticeable throughout addiction research and within the foundations of disease modelling. The availability of methods to investigate substance use disorder are inconsistent and sometimes unrepresentative. This review discusses theories of addiction aetiology, available models for addiction research and the strengths and limitations of current practical experimental methods of study. Frontiers Media S.A. 2023-09-06 /pmc/articles/PMC10511750/ /pubmed/37745284 http://dx.doi.org/10.3389/fnmol.2023.1166852 Text en Copyright © 2023 Greener and Storr. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Greener, Megan R.
Storr, Sarah J.
Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title_full Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title_fullStr Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title_full_unstemmed Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title_short Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
title_sort conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511750/
https://www.ncbi.nlm.nih.gov/pubmed/37745284
http://dx.doi.org/10.3389/fnmol.2023.1166852
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