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The adenylate cyclase toxin RTX domain follows a series templated folding mechanism with implications for toxin activity

Folding of the Repeats-in-toxin (RTX) domain of the bacterial adenylate cyclase toxin-hemolysin (CyaA) is critical to its toxin activities and the virulence of the whooping cough agent Bordetella pertussis. The RTX domain (RD) contains five RTX blocks (RTX-i to RTX-v) and their folding is driven by...

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Detalles Bibliográficos
Autores principales:	Chen, Guojun, Wang, Han, Bumba, Ladislav, Masin, Jiri, Sebo, Peter, Li, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511787/ https://www.ncbi.nlm.nih.gov/pubmed/37567473 http://dx.doi.org/10.1016/j.jbc.2023.105150

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