Natural mutations of human XDH promote the nitrite (NO(2)(−))-reductase capacity of xanthine oxidoreductase: A novel mechanism to promote redox health?

Several rare genetic variations of human XDH have been shown to alter xanthine oxidoreductase (XOR) activity leading to impaired purine catabolism. However, XOR is a multi-functional enzyme that depending upon the environmental conditions also expresses oxidase activity leading to both O(2)(·-) and...

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Detalles Bibliográficos
Autores principales: Massimo, G., Khambata, R.S., Chapman, T., Birchall, K., Raimondi, C., Shabbir, A., Dyson, Nicki, Rathod, K.S., Borghi, C., Ahluwalia, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511815/
https://www.ncbi.nlm.nih.gov/pubmed/37713777
http://dx.doi.org/10.1016/j.redox.2023.102864

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