Enolase represents a metabolic checkpoint controlling the differential exhaustion programmes of hepatitis virus-specific CD8(+) T cells

OBJECTIVE: Exhausted T cells with limited effector function are enriched in chronic hepatitis B and C virus (HBV and HCV) infection. Metabolic regulation contributes to exhaustion, but it remains unclear how metabolism relates to different exhaustion states, is impacted by antiviral therapy, and if...

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Detalles Bibliográficos
Autores principales: Winkler, Frances, Hipp, Anna V, Ramirez, Carlos, Martin, Bianca, Villa, Matteo, Neuwirt, Emilia, Gorka, Oliver, Aerssens, Jeroen, Johansson, Susanne E, Rana, Nisha, Llewellyn-Lacey, Sian, Price, David A, Panning, Marcus, Groß, Olaf, Pearce, Erika L, Hermann, Carl M, Schumann, Kathrin, Hannibal, Luciana, Neumann-Haefelin, Christoph, Boettler, Tobias, Knolle, Percy, Hofmann, Maike, Wohlleber, Dirk, Thimme, Robert, Bengsch, Bertram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511960/
https://www.ncbi.nlm.nih.gov/pubmed/37541771
http://dx.doi.org/10.1136/gutjnl-2022-328734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10511960/
https://www.ncbi.nlm.nih.gov/pubmed/37541771
http://dx.doi.org/10.1136/gutjnl-2022-328734

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