Innate and adaptive AAV-mediated immune responses in a mouse model of Duchenne muscular dystrophy

High systemic doses of adeno-associated viruses (AAVs) have been associated with immune-related serious adverse events (SAEs). Although AAV was well tolerated in preclinical models, SAEs were observed in clinical trials, indicating the need for improved preclinical models to understand AAV-induced i...

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Detalles Bibliográficos
Autores principales: Emami, Michael R., Espinoza, Alejandro, Young, Courtney S., Ma, Feiyang, Farahat, Philip K., Felgner, Philip L., Chamberlain, Jeffrey S., Xu, Xiangmin, Pyle, April D., Pellegrini, Matteo, Villalta, S. Armando, Spencer, Melissa J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512012/
https://www.ncbi.nlm.nih.gov/pubmed/37746243
http://dx.doi.org/10.1016/j.omtm.2023.06.002

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