In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans

Anc80L65 is a synthetic, ancestral adeno-associated virus that has high tropism toward retinal photoreceptors after subretinal injection in mice and non-human primates. We characterized, for the first time, the post-intravitreal cell-specific transduction profile of Anc80L65 compared with AAV9. Here...

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Detalles Bibliográficos
Autores principales: Schwartz, Maura K., Likhite, Shibi, Vetter, Tatyana A., Baird, Megan C., McGovern, Vicki, Sierra Delgado, Andrea, Mendel, Tom, Burghes, Arthur, Meyer, Kathrin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512013/
https://www.ncbi.nlm.nih.gov/pubmed/37746244
http://dx.doi.org/10.1016/j.omtm.2023.05.016

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