Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system

Current manufacturing processes for recombinant adeno-associated viruses (rAAVs) have less-than-desired yields and produce significant amounts of empty capsids. The increasing demand and the high cost of goods for rAAV-based gene therapies motivate development of more efficient manufacturing process...

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Detalles Bibliográficos
Autores principales: Destro, Francesco, Joseph, John, Srinivasan, Prasanna, Kanter, Joshua M., Neufeld, Caleb, Wolfrum, Jacqueline M., Barone, Paul W., Springs, Stacy L., Sinskey, Anthony J., Cecchini, Sylvain, Kotin, Robert M., Braatz, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512016/
https://www.ncbi.nlm.nih.gov/pubmed/37746245
http://dx.doi.org/10.1016/j.omtm.2023.05.019

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