Structural biology of SMC complexes across the tree of life

Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the complexes move along their substrate. Here, w...

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Detalles Bibliográficos
Autores principales: Bürmann, Frank, Löwe, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512200/
https://www.ncbi.nlm.nih.gov/pubmed/37104976
http://dx.doi.org/10.1016/j.sbi.2023.102598
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author Bürmann, Frank
Löwe, Jan
author_facet Bürmann, Frank
Löwe, Jan
author_sort Bürmann, Frank
collection PubMed
description Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the complexes move along their substrate. Here, we review recent structural insights into the architecture and conservation of these molecular machines, their interaction with DNA, and the conformational changes that are linked to their ATP hydrolysis cycle.
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spelling pubmed-105122002023-09-22 Structural biology of SMC complexes across the tree of life Bürmann, Frank Löwe, Jan Curr Opin Struct Biol Article Structural maintenance of chromosomes (SMC) complexes guard and organize the three-dimensional structure of chromosomal DNA across the tree of life. Many SMC functions can be explained by an inherent motor activity that extrudes large DNA loops while the complexes move along their substrate. Here, we review recent structural insights into the architecture and conservation of these molecular machines, their interaction with DNA, and the conformational changes that are linked to their ATP hydrolysis cycle. Elsevier Science 2023-06 /pmc/articles/PMC10512200/ /pubmed/37104976 http://dx.doi.org/10.1016/j.sbi.2023.102598 Text en © 2023 MRC Laboratory of Molecular Biology https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bürmann, Frank
Löwe, Jan
Structural biology of SMC complexes across the tree of life
title Structural biology of SMC complexes across the tree of life
title_full Structural biology of SMC complexes across the tree of life
title_fullStr Structural biology of SMC complexes across the tree of life
title_full_unstemmed Structural biology of SMC complexes across the tree of life
title_short Structural biology of SMC complexes across the tree of life
title_sort structural biology of smc complexes across the tree of life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512200/
https://www.ncbi.nlm.nih.gov/pubmed/37104976
http://dx.doi.org/10.1016/j.sbi.2023.102598
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