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The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment
Antifungal resistance in humans, animals, and the environment is an emerging problem. Among the different fungal species that can develop resistance, Candida tropicalis is ubiquitous and causes infections in animals and humans. In Asia and some Latin American countries, C. tropicalis is among the mo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512401/ https://www.ncbi.nlm.nih.gov/pubmed/37746212 http://dx.doi.org/10.3389/ffunb.2022.957021 |
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author | Lima, Ricardo Ribeiro, Felipe C. Colombo, Arnaldo L. de Almeida, Joăo N. |
author_facet | Lima, Ricardo Ribeiro, Felipe C. Colombo, Arnaldo L. de Almeida, Joăo N. |
author_sort | Lima, Ricardo |
collection | PubMed |
description | Antifungal resistance in humans, animals, and the environment is an emerging problem. Among the different fungal species that can develop resistance, Candida tropicalis is ubiquitous and causes infections in animals and humans. In Asia and some Latin American countries, C. tropicalis is among the most common species related to candidemia, and mortality rates are usually above 40%. Fluconazole resistance is especially reported in Asian countries and clonal spread in humans and the environment has been investigated in some studies. In Brazil, high rates of azole resistance have been found in animals and the environment. Multidrug resistance is still rare, but recent reports of clinical multidrug-resistant isolates are worrisome. The molecular apparatus of antifungal resistance has been majorly investigated in clinical C. tropicalis isolates, revealing that this species can develop resistance through the conjunction of different adaptative mechanisms. In this review article, we summarize the main findings regarding antifungal resistance and Candida tropicalis through an “One Health” approach. |
format | Online Article Text |
id | pubmed-10512401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105124012023-09-22 The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment Lima, Ricardo Ribeiro, Felipe C. Colombo, Arnaldo L. de Almeida, Joăo N. Front Fungal Biol Fungal Biology Antifungal resistance in humans, animals, and the environment is an emerging problem. Among the different fungal species that can develop resistance, Candida tropicalis is ubiquitous and causes infections in animals and humans. In Asia and some Latin American countries, C. tropicalis is among the most common species related to candidemia, and mortality rates are usually above 40%. Fluconazole resistance is especially reported in Asian countries and clonal spread in humans and the environment has been investigated in some studies. In Brazil, high rates of azole resistance have been found in animals and the environment. Multidrug resistance is still rare, but recent reports of clinical multidrug-resistant isolates are worrisome. The molecular apparatus of antifungal resistance has been majorly investigated in clinical C. tropicalis isolates, revealing that this species can develop resistance through the conjunction of different adaptative mechanisms. In this review article, we summarize the main findings regarding antifungal resistance and Candida tropicalis through an “One Health” approach. Frontiers Media S.A. 2022-08-15 /pmc/articles/PMC10512401/ /pubmed/37746212 http://dx.doi.org/10.3389/ffunb.2022.957021 Text en Copyright © 2022 Lima, Ribeiro, Colombo and de Almeida https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Fungal Biology Lima, Ricardo Ribeiro, Felipe C. Colombo, Arnaldo L. de Almeida, Joăo N. The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title | The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title_full | The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title_fullStr | The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title_full_unstemmed | The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title_short | The emerging threat antifungal-resistant Candida tropicalis in humans, animals, and environment |
title_sort | emerging threat antifungal-resistant candida tropicalis in humans, animals, and environment |
topic | Fungal Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512401/ https://www.ncbi.nlm.nih.gov/pubmed/37746212 http://dx.doi.org/10.3389/ffunb.2022.957021 |
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