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Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis

Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However...

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Autores principales: Jameson, J. Brian, Wang, Jiaming, Bailey, Patrick C., Oldham, Michael J., Smith, Cameron R., Jeong, Lena N., Cook, David K., Bates, Austin L., Ullah, Sifat, Pennington, Alexander S. C., Gillman, I. Gene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/
https://www.ncbi.nlm.nih.gov/pubmed/37744056
http://dx.doi.org/10.3389/fchem.2023.1223967
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author Jameson, J. Brian
Wang, Jiaming
Bailey, Patrick C.
Oldham, Michael J.
Smith, Cameron R.
Jeong, Lena N.
Cook, David K.
Bates, Austin L.
Ullah, Sifat
Pennington, Alexander S. C.
Gillman, I. Gene
author_facet Jameson, J. Brian
Wang, Jiaming
Bailey, Patrick C.
Oldham, Michael J.
Smith, Cameron R.
Jeong, Lena N.
Cook, David K.
Bates, Austin L.
Ullah, Sifat
Pennington, Alexander S. C.
Gillman, I. Gene
author_sort Jameson, J. Brian
collection PubMed
description Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested.
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spelling pubmed-105124642023-09-22 Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene Front Chem Chemistry Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10512464/ /pubmed/37744056 http://dx.doi.org/10.3389/fchem.2023.1223967 Text en Copyright © 2023 Jameson, Wang, Bailey, Oldham, Smith, Jeong, Cook, Bates, Ullah, Pennington and Gillman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Jameson, J. Brian
Wang, Jiaming
Bailey, Patrick C.
Oldham, Michael J.
Smith, Cameron R.
Jeong, Lena N.
Cook, David K.
Bates, Austin L.
Ullah, Sifat
Pennington, Alexander S. C.
Gillman, I. Gene
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title_full Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title_fullStr Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title_full_unstemmed Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title_short Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
title_sort determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/
https://www.ncbi.nlm.nih.gov/pubmed/37744056
http://dx.doi.org/10.3389/fchem.2023.1223967
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