Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1

BACKGROUND: Nuclear receptors NUR77 and NOR1 were identified as critical targets in acute myeloid leukemia (AML) therapy. Previously, we showed that Z-ligustilide (Z-LIG) selectively targeted AML by restoring NUR77 and NOR1. However, its downstream mechanisms are yet to be elucidated. METHODS: SRB s...

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Detalles Bibliográficos
Autores principales: Liu, Gen, Chen, Zhi-gang, Yang, Li-rong, Rong, Yu-xia, Wang, Qin, Li, Li, Lu, Qian-wei, Jiang, Ming-dong, Qi, Hong-yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512564/
https://www.ncbi.nlm.nih.gov/pubmed/37735686
http://dx.doi.org/10.1186/s13020-023-00808-7

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