Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone

Radiation-induced lung injury (RILI) associated with lung cancer becomes refractory. Nintedanib is a multi-kinase inhibitor that suppresses the development of pulmonary fibrosis. Herein, we report a case of RILI with progressive pulmonary fibrosis after stereotactic body radiation therapy in a 70-ye...

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Detalles Bibliográficos
Autores principales: Itano, Junko, Kimura, Goro, Ninomiya, Kiichiro, Tanimoto, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512623/
https://www.ncbi.nlm.nih.gov/pubmed/37745734
http://dx.doi.org/10.7759/cureus.45678
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author Itano, Junko
Kimura, Goro
Ninomiya, Kiichiro
Tanimoto, Yasushi
author_facet Itano, Junko
Kimura, Goro
Ninomiya, Kiichiro
Tanimoto, Yasushi
author_sort Itano, Junko
collection PubMed
description Radiation-induced lung injury (RILI) associated with lung cancer becomes refractory. Nintedanib is a multi-kinase inhibitor that suppresses the development of pulmonary fibrosis. Herein, we report a case of RILI with progressive pulmonary fibrosis after stereotactic body radiation therapy in a 70-year-old man with lung cancer. The patient responded well to the initial prednisolone therapy but became resistant during tapering. The combination therapy of nintedanib and dexamethasone resulted in a temporary improvement in RILI. Nintedanib is not a standard therapy for RILI, and further investigation is needed to evaluate the effects of nintedanib on RILI complicated by lung cancer.
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spelling pubmed-105126232023-09-22 Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone Itano, Junko Kimura, Goro Ninomiya, Kiichiro Tanimoto, Yasushi Cureus Internal Medicine Radiation-induced lung injury (RILI) associated with lung cancer becomes refractory. Nintedanib is a multi-kinase inhibitor that suppresses the development of pulmonary fibrosis. Herein, we report a case of RILI with progressive pulmonary fibrosis after stereotactic body radiation therapy in a 70-year-old man with lung cancer. The patient responded well to the initial prednisolone therapy but became resistant during tapering. The combination therapy of nintedanib and dexamethasone resulted in a temporary improvement in RILI. Nintedanib is not a standard therapy for RILI, and further investigation is needed to evaluate the effects of nintedanib on RILI complicated by lung cancer. Cureus 2023-09-21 /pmc/articles/PMC10512623/ /pubmed/37745734 http://dx.doi.org/10.7759/cureus.45678 Text en Copyright © 2023, Itano et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Itano, Junko
Kimura, Goro
Ninomiya, Kiichiro
Tanimoto, Yasushi
Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title_full Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title_fullStr Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title_full_unstemmed Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title_short Radiation-Induced Lung Injury With Lung Cancer Treated With the Combination Therapy of Nintedanib and Dexamethasone
title_sort radiation-induced lung injury with lung cancer treated with the combination therapy of nintedanib and dexamethasone
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512623/
https://www.ncbi.nlm.nih.gov/pubmed/37745734
http://dx.doi.org/10.7759/cureus.45678
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