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Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation

BACKGROUND: Aging is frequently associated with impairments of the musculoskeletal system and many elderly people experience joint discomfort or pain which might reduce their ability to move and consequently alter their quality of life. A beneficial effect of fish cartilage hydrolysate (FCH) on pain...

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Autores principales: Yves, Henrotin, Herman, Julie, Uebelhoer, Melanie, Wauquier, Fabien, Boutin-Wittrant, Line, Donneau, Anne-Françoise, Monseur, Justine, Fotso, Variance Mokam, Duquenne, Marie, Wagner, Mélanie, Bouvret, Elodie, Costes, Bérénice, Wittrant, Yohann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512646/
https://www.ncbi.nlm.nih.gov/pubmed/37735385
http://dx.doi.org/10.1186/s12891-023-06800-4
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author Yves, Henrotin
Herman, Julie
Uebelhoer, Melanie
Wauquier, Fabien
Boutin-Wittrant, Line
Donneau, Anne-Françoise
Monseur, Justine
Fotso, Variance Mokam
Duquenne, Marie
Wagner, Mélanie
Bouvret, Elodie
Costes, Bérénice
Wittrant, Yohann
author_facet Yves, Henrotin
Herman, Julie
Uebelhoer, Melanie
Wauquier, Fabien
Boutin-Wittrant, Line
Donneau, Anne-Françoise
Monseur, Justine
Fotso, Variance Mokam
Duquenne, Marie
Wagner, Mélanie
Bouvret, Elodie
Costes, Bérénice
Wittrant, Yohann
author_sort Yves, Henrotin
collection PubMed
description BACKGROUND: Aging is frequently associated with impairments of the musculoskeletal system and many elderly people experience joint discomfort or pain which might reduce their ability to move and consequently alter their quality of life. A beneficial effect of fish cartilage hydrolysate (FCH) on pain and joint function has recently been shown in an ACLT/pMMx osteoarthritis rat model. METHODS: We therefore performed an exploratory, non-comparative, multi-centric clinical trial including 33 subjects with moderate knee joint discomfort and loss of functionality to investigate the efficacy of FCH on their algo-functional status. We further determined the potential health benefit of FCH in an original clinical ex vivo study investigating the role of FCH human metabolites on primary human chondrocytes. RESULTS: FCH significantly improved knee pain and function, as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). Moreover, FCH significantly reduced pain at rest and while walking, and patient global assessment (PGA), as assessed by the Visual Analogue Scale (VAS), and improved patients’ quality of life (SF-36). FCH metabolites decreased the synthesis of catabolic factors (MMP-13) and pro-inflammatory mediators (NO, PGE2) and limited the inhibitory effect of IL-1β on the synthesis of cartilage matrix components (GAG and collagen). CONCLUSIONS: Thus, these data provide insights on the mode of action of FCH in humans and contribute to explain how FCH may relieve pain and improve joint function in subjects with knee discomfort. Although these preliminary data need to be confirmed in a randomized controlled trial, they strongly support the potential health benefit of such an active ingredient. Trial registration: The study was registered on clinicaltrials.gov with the identifier NCT04420091 (09/06/2020). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-023-06800-4.
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spelling pubmed-105126462023-09-22 Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation Yves, Henrotin Herman, Julie Uebelhoer, Melanie Wauquier, Fabien Boutin-Wittrant, Line Donneau, Anne-Françoise Monseur, Justine Fotso, Variance Mokam Duquenne, Marie Wagner, Mélanie Bouvret, Elodie Costes, Bérénice Wittrant, Yohann BMC Musculoskelet Disord Research BACKGROUND: Aging is frequently associated with impairments of the musculoskeletal system and many elderly people experience joint discomfort or pain which might reduce their ability to move and consequently alter their quality of life. A beneficial effect of fish cartilage hydrolysate (FCH) on pain and joint function has recently been shown in an ACLT/pMMx osteoarthritis rat model. METHODS: We therefore performed an exploratory, non-comparative, multi-centric clinical trial including 33 subjects with moderate knee joint discomfort and loss of functionality to investigate the efficacy of FCH on their algo-functional status. We further determined the potential health benefit of FCH in an original clinical ex vivo study investigating the role of FCH human metabolites on primary human chondrocytes. RESULTS: FCH significantly improved knee pain and function, as assessed by the Knee injury and Osteoarthritis Outcome Score (KOOS). Moreover, FCH significantly reduced pain at rest and while walking, and patient global assessment (PGA), as assessed by the Visual Analogue Scale (VAS), and improved patients’ quality of life (SF-36). FCH metabolites decreased the synthesis of catabolic factors (MMP-13) and pro-inflammatory mediators (NO, PGE2) and limited the inhibitory effect of IL-1β on the synthesis of cartilage matrix components (GAG and collagen). CONCLUSIONS: Thus, these data provide insights on the mode of action of FCH in humans and contribute to explain how FCH may relieve pain and improve joint function in subjects with knee discomfort. Although these preliminary data need to be confirmed in a randomized controlled trial, they strongly support the potential health benefit of such an active ingredient. Trial registration: The study was registered on clinicaltrials.gov with the identifier NCT04420091 (09/06/2020). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12891-023-06800-4. BioMed Central 2023-09-21 /pmc/articles/PMC10512646/ /pubmed/37735385 http://dx.doi.org/10.1186/s12891-023-06800-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yves, Henrotin
Herman, Julie
Uebelhoer, Melanie
Wauquier, Fabien
Boutin-Wittrant, Line
Donneau, Anne-Françoise
Monseur, Justine
Fotso, Variance Mokam
Duquenne, Marie
Wagner, Mélanie
Bouvret, Elodie
Costes, Bérénice
Wittrant, Yohann
Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title_full Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title_fullStr Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title_full_unstemmed Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title_short Oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
title_sort oral supplementation with fish cartilage hydrolysate in an adult population suffering from knee pain and function discomfort: results from an innovative approach combining an exploratory clinical study and an ex vivo clinical investigation
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512646/
https://www.ncbi.nlm.nih.gov/pubmed/37735385
http://dx.doi.org/10.1186/s12891-023-06800-4
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