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Impact of negative symptoms on health-related quality of life in schizophrenia
Evidence regarding the association of Negative Symptoms (NS) dimensions with Health-related Quality of Life (HRQoL) is limited and no prior study has looked into contributions of NS domains on HRQoL. This study bridges the gap by examining the associations of NS, its two dimensions (Motivation and P...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512711/ https://www.ncbi.nlm.nih.gov/pubmed/37744001 http://dx.doi.org/10.3389/fpsyt.2023.1252354 |
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author | Li, Yanhui Rekhi, Gurpreet Ang, Mei San Lee, Jimmy |
author_facet | Li, Yanhui Rekhi, Gurpreet Ang, Mei San Lee, Jimmy |
author_sort | Li, Yanhui |
collection | PubMed |
description | Evidence regarding the association of Negative Symptoms (NS) dimensions with Health-related Quality of Life (HRQoL) is limited and no prior study has looked into contributions of NS domains on HRQoL. This study bridges the gap by examining the associations of NS, its two dimensions (Motivation and Pleasure, and Emotional Expressivity) and five domains (Anhedonia, Avolition, Asociality, Blunted affect and Alogia) with HRQoL in schizophrenia. 274 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptom Scale (BNSS). PANSS scores were mapped to EuroQol five-dimensional (EQ-5D-5L) utility scores using an algorithm previously validated in Singapore, and the resulting EQ-5D-5L scores were used as a measure of HRQoL. Multiple linear regression analyses of the two NS dimensions and five NS domains against EQ-5D-5L showed that a lower severity of NS, specifically that of the Motivation and Pleasure (MAP) dimension and asociality domain was associated with higher HRQoL. Our findings highlight the importance of targeting NS, particularly MAP and asociality, in improving HRQoL in schizophrenia. |
format | Online Article Text |
id | pubmed-10512711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105127112023-09-22 Impact of negative symptoms on health-related quality of life in schizophrenia Li, Yanhui Rekhi, Gurpreet Ang, Mei San Lee, Jimmy Front Psychiatry Psychiatry Evidence regarding the association of Negative Symptoms (NS) dimensions with Health-related Quality of Life (HRQoL) is limited and no prior study has looked into contributions of NS domains on HRQoL. This study bridges the gap by examining the associations of NS, its two dimensions (Motivation and Pleasure, and Emotional Expressivity) and five domains (Anhedonia, Avolition, Asociality, Blunted affect and Alogia) with HRQoL in schizophrenia. 274 individuals with schizophrenia were assessed on the Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptom Scale (BNSS). PANSS scores were mapped to EuroQol five-dimensional (EQ-5D-5L) utility scores using an algorithm previously validated in Singapore, and the resulting EQ-5D-5L scores were used as a measure of HRQoL. Multiple linear regression analyses of the two NS dimensions and five NS domains against EQ-5D-5L showed that a lower severity of NS, specifically that of the Motivation and Pleasure (MAP) dimension and asociality domain was associated with higher HRQoL. Our findings highlight the importance of targeting NS, particularly MAP and asociality, in improving HRQoL in schizophrenia. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10512711/ /pubmed/37744001 http://dx.doi.org/10.3389/fpsyt.2023.1252354 Text en Copyright © 2023 Li, Rekhi, Ang and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Li, Yanhui Rekhi, Gurpreet Ang, Mei San Lee, Jimmy Impact of negative symptoms on health-related quality of life in schizophrenia |
title | Impact of negative symptoms on health-related quality of life in schizophrenia |
title_full | Impact of negative symptoms on health-related quality of life in schizophrenia |
title_fullStr | Impact of negative symptoms on health-related quality of life in schizophrenia |
title_full_unstemmed | Impact of negative symptoms on health-related quality of life in schizophrenia |
title_short | Impact of negative symptoms on health-related quality of life in schizophrenia |
title_sort | impact of negative symptoms on health-related quality of life in schizophrenia |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512711/ https://www.ncbi.nlm.nih.gov/pubmed/37744001 http://dx.doi.org/10.3389/fpsyt.2023.1252354 |
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