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Pain catastrophizing is associated with reduced neural response to monetary reward

INTRODUCTION: Pain catastrophizing, a measure of an individual's negative emotional and cognitive appraisals of pain, has been included as a key treatment target in many psychological interventions for pain. However, the neural correlates of pain catastrophizing have been understudied. Prior ne...

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Autores principales: Cooke, Megan E., Edwards, Robert R., Wheeler, Grace L., Schmitt, William A., Nielsen, Lindsay V., Streck, Joanna M., Schuster, Randi M., Potter, Kevin, Evins, A. Eden, Gilman, Jodi M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512714/
https://www.ncbi.nlm.nih.gov/pubmed/37745802
http://dx.doi.org/10.3389/fpain.2023.1129353
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author Cooke, Megan E.
Edwards, Robert R.
Wheeler, Grace L.
Schmitt, William A.
Nielsen, Lindsay V.
Streck, Joanna M.
Schuster, Randi M.
Potter, Kevin
Evins, A. Eden
Gilman, Jodi M.
author_facet Cooke, Megan E.
Edwards, Robert R.
Wheeler, Grace L.
Schmitt, William A.
Nielsen, Lindsay V.
Streck, Joanna M.
Schuster, Randi M.
Potter, Kevin
Evins, A. Eden
Gilman, Jodi M.
author_sort Cooke, Megan E.
collection PubMed
description INTRODUCTION: Pain catastrophizing, a measure of an individual's negative emotional and cognitive appraisals of pain, has been included as a key treatment target in many psychological interventions for pain. However, the neural correlates of pain catastrophizing have been understudied. Prior neuroimaging evidence suggests that adults with pain show altered reward processing throughout the mesocorticolimbic reward circuitry. METHODS: In this study, we tested the association between Pain Catastrophizing Scale (PCS) scores and neural activation to the Monetary Incentive Delay (MID) reward neuroimaging task in 94 adults reporting a range of pain, insomnia, and mood symptoms. RESULTS: Results indicated that PCS score but not pain intensity was significantly associated with blunted activation in the caudate and putamen in response to feedback of successful vs. unsuccessful trials on the MID task. Mediation analyses indicated that PCS score fully mediated the relationship between depression symptoms and reward activation. DISCUSSION: These findings provide evidence that pain catastrophizing is independently associated with altered striatal function apart from depression symptoms and pain intensity. Thus, in individuals experiencing pain and/or co- morbid conditions, reward dysfunction is directly related to pain catastrophizing.
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spelling pubmed-105127142023-09-22 Pain catastrophizing is associated with reduced neural response to monetary reward Cooke, Megan E. Edwards, Robert R. Wheeler, Grace L. Schmitt, William A. Nielsen, Lindsay V. Streck, Joanna M. Schuster, Randi M. Potter, Kevin Evins, A. Eden Gilman, Jodi M. Front Pain Res (Lausanne) Pain Research INTRODUCTION: Pain catastrophizing, a measure of an individual's negative emotional and cognitive appraisals of pain, has been included as a key treatment target in many psychological interventions for pain. However, the neural correlates of pain catastrophizing have been understudied. Prior neuroimaging evidence suggests that adults with pain show altered reward processing throughout the mesocorticolimbic reward circuitry. METHODS: In this study, we tested the association between Pain Catastrophizing Scale (PCS) scores and neural activation to the Monetary Incentive Delay (MID) reward neuroimaging task in 94 adults reporting a range of pain, insomnia, and mood symptoms. RESULTS: Results indicated that PCS score but not pain intensity was significantly associated with blunted activation in the caudate and putamen in response to feedback of successful vs. unsuccessful trials on the MID task. Mediation analyses indicated that PCS score fully mediated the relationship between depression symptoms and reward activation. DISCUSSION: These findings provide evidence that pain catastrophizing is independently associated with altered striatal function apart from depression symptoms and pain intensity. Thus, in individuals experiencing pain and/or co- morbid conditions, reward dysfunction is directly related to pain catastrophizing. Frontiers Media S.A. 2023-09-07 /pmc/articles/PMC10512714/ /pubmed/37745802 http://dx.doi.org/10.3389/fpain.2023.1129353 Text en © 2023 Cooke, Edwards, Wheeler, Schmitt, Nielsen, Streck, Schuster, Potter, Evins and Gilman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pain Research
Cooke, Megan E.
Edwards, Robert R.
Wheeler, Grace L.
Schmitt, William A.
Nielsen, Lindsay V.
Streck, Joanna M.
Schuster, Randi M.
Potter, Kevin
Evins, A. Eden
Gilman, Jodi M.
Pain catastrophizing is associated with reduced neural response to monetary reward
title Pain catastrophizing is associated with reduced neural response to monetary reward
title_full Pain catastrophizing is associated with reduced neural response to monetary reward
title_fullStr Pain catastrophizing is associated with reduced neural response to monetary reward
title_full_unstemmed Pain catastrophizing is associated with reduced neural response to monetary reward
title_short Pain catastrophizing is associated with reduced neural response to monetary reward
title_sort pain catastrophizing is associated with reduced neural response to monetary reward
topic Pain Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512714/
https://www.ncbi.nlm.nih.gov/pubmed/37745802
http://dx.doi.org/10.3389/fpain.2023.1129353
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